Once-daily dosing of amikacin for treatment of Mycobacterium abscessus lung disease
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Sohn, You Min | - |
dc.contributor.author | Lee, Soo-youn | - |
dc.contributor.author | Ko, J.Y. | - |
dc.contributor.author | Jhun, Byung-woo | - |
dc.contributor.author | Park, Hye-yun | - |
dc.contributor.author | Jeon, Kyeongman | - |
dc.contributor.author | Kim, Dae-hun | - |
dc.contributor.author | Kim, Su-young | - |
dc.contributor.author | Choi, Ji-eun | - |
dc.contributor.author | Moon, Il-joon | - |
dc.contributor.author | Shin, Sung-jae | - |
dc.contributor.author | Park, Hyojung | - |
dc.contributor.author | Koh, Wonjung | - |
dc.date.accessioned | 2021-07-30T05:12:07Z | - |
dc.date.available | 2021-07-30T05:12:07Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3508 | - |
dc.description.abstract | SETTING: Tertiary referral centre, Samsung Medical Center, South Korea. OBJECTIVE: To evaluate the pharmacokinetic parameters and toxicities of once-daily amikacin (AMK) dosing for lung disease due to Mycobacterium abscessus. DESIGN: A retrospective review of 48 patients with M. abscessus lung disease who received once-daily AMK for 4 weeks between January 2012 and June 2015. RESULTS: With a starting dose of 15 mg/kg/day and adjustment of AMK dose according to the peak serum level (C-max), the C-max target of 55-65 mu g/ml was achieved in 31.3% (15/48) of patients in the first week, 68.8% (33/48) in week 2, 91.7% (44/48) in week 3 and 95.8% (46/48) in week 4. Transient nephrotoxicity developed in 6.3% (3/48) of patients and ototoxicity in 25.0% (6/24), which was determined by audiogram as hearing loss, asymptomatic in five patients and tinnitus in one. Multivariate analysis revealed that the highest drug concentration 12 h after administration was significantly associated with the development of toxicities (adjusted odds ratio 1.862, P = 0.047). CONCLUSION: Our results suggest that once-daily AMK for 4 weeks with a target C-max of 55-65 mu g/ml can be used in patients with M. abscessus lung disease, with careful monitoring of toxicity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | - |
dc.title | Once-daily dosing of amikacin for treatment of Mycobacterium abscessus lung disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun | - |
dc.identifier.doi | 10.5588/ijtld.16.0791 | - |
dc.identifier.scopusid | 2-s2.0-85021095721 | - |
dc.identifier.wosid | 000406254900018 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.21, no.7, pp.818 - 824 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.citation.volume | 21 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 818 | - |
dc.citation.endPage | 824 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | RAPIDLY GROWING MYCOBACTERIA | - |
dc.subject.keywordPlus | PULMONARY-DISEASE | - |
dc.subject.keywordPlus | SUBSP ABSCESSUS | - |
dc.subject.keywordPlus | NONTUBERCULOUS MYCOBACTERIA | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | BOLLETII | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | MASSILIENSE | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordAuthor | non-tuberculous mycobacteria | - |
dc.subject.keywordAuthor | M. abscessus | - |
dc.subject.keywordAuthor | AMK | - |
dc.subject.keywordAuthor | nephrotoxicity | - |
dc.subject.keywordAuthor | ototoxicity | - |
dc.identifier.url | https://www.ingentaconnect.com/content/iuatld/ijtld/2017/00000021/00000007/art00018 | - |
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