Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-07-30T05:12:09Z | - |
dc.date.available | 2021-07-30T05:12:09Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 0032-5481 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3516 | - |
dc.description.abstract | Objective: We evaluated the relationship between calprotectin levels and rheumatoid arthritis (RA), and the correlation between plasma/serum calprotectin and RA activity. Methods: We searched PUBMED, EMBASE, and Cochrane databases and performed meta-analyses comparing plasma/serum or synovial fluid calprotectin levels in RA patients and controls, and correlation coefficients between calprotectin levels and disease activity for 28 joints (DAS28) as well as C-reactive protein (CRP) in RA patients. Results: Sixteen studies including 849 RA patients and 266 controls were available for meta-analysis. Meta-analysis showed that calprotectin levels were significantly higher in the RA group than in the control group (SMD = 2.337, 95% CI = 1.544-3.130, p < 1.0x10(-8)). Stratification by rheumatoid factor (RF) status revealed significantly elevated calprotectin levels in the RF-positive RA group compared to that of the RF-negative RA group (SMD = 0.574, 95% CI = 0.345-0.804, p = 9.2x10(-7)). Meta-analysis of correlation coefficients identified a significant positive correlation between calprotectin levels and CRP or DAS28 (correlation coefficient for CRP = 0.566, 95% CI = 0.512-0.615, p < 1.0x10(-8); correlation coefficient for DAS28 = 0.438, 95% CI = 0.269-0.518, p = 2.5x10(-6)). Calprotectin levels in synovial fluid were significantly higher in the RA group than in the control group (SMD = 2.891, 95% CI = 1.067-4.715, p = 0.002). Conclusions: Our meta-analysis demonstrates that circulating and synovial fluid calprotectin levels are high in patients with RA, and that circulating calprotectin levels positively correlate with RA activity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1080/00325481.2017.1319729 | - |
dc.identifier.scopusid | 2-s2.0-85018827067 | - |
dc.identifier.wosid | 000402724300006 | - |
dc.identifier.bibliographicCitation | POSTGRADUATE MEDICINE, v.129, no.5, pp.531 - 537 | - |
dc.relation.isPartOf | POSTGRADUATE MEDICINE | - |
dc.citation.title | POSTGRADUATE MEDICINE | - |
dc.citation.volume | 129 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 531 | - |
dc.citation.endPage | 537 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MAJOR LEUKOCYTE PROTEIN | - |
dc.subject.keywordPlus | SERUM CALPROTECTIN | - |
dc.subject.keywordPlus | JOINT | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | S100A8/A9 | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | CALGRANULINS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordAuthor | Calprotectin | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | activity | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/00325481.2017.1319729 | - |
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