Clinical features and outcomes of patients with hepatocellular carcinoma complicated with bile duct invasion
DC Field | Value | Language |
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dc.contributor.author | An, Ji hyun | - |
dc.contributor.author | Lee, Kwang Sun | - |
dc.contributor.author | Kim, Kang Mo | - |
dc.contributor.author | Park, Do Hyun | - |
dc.contributor.author | Lee, Sang Soo | - |
dc.contributor.author | Lee, Danbi | - |
dc.contributor.author | Shim, Ju Hyun | - |
dc.contributor.author | Lim, Young-Suk | - |
dc.contributor.author | Lee, Han Chu | - |
dc.contributor.author | Chung, Young-Hwa | - |
dc.contributor.author | Lee, Yung Sang | - |
dc.date.accessioned | 2021-07-30T05:12:11Z | - |
dc.date.available | 2021-07-30T05:12:11Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 2287-2728 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3524 | - |
dc.description.abstract | Background/Aims Little is known about the treatment or outcomes of hepatocellular carcinoma (HCC) complicated with bile duct invasion. Methods A total of 247 consecutive HCC patients with bile duct invasion at initial diagnosis were retrospectively included. Results The majority of patients had Barcelona Clinic Liver Cancer (BCLC) stage C HCC (66.8%). Portal vein tumor thrombosis was present in 166 (67.2%) patients. Median survival was 4.1 months. Various modalities of treatment were initially employed including surgical resection (10.9%), repeated transarterial chemoembolization (TACE) (42.5%), and conservative management (42.9%). Among the patients with obstructive jaundice (n=88), successful biliary drainage was associated with better overall survival rate. Among the patients with BCLC stage C, overall survival differed depending on the initial treatment for HCC; surgical resection, TACE, systemic chemotherapy, and conservative management showed overall survival rates of 11.5, 6.0 ,2.4, and 1.6 months, respectively. After adjusting for confounders, surgical resection and repeated TACE were significant prognostic factors for HCC patients with bile duct invasion (hazard ratios 0.47 and 0.39, Ps <0.001, respectively). Conclusions The survival of HCC patients with bile duct invasion at initial diagnosis is generally poor. However, aggressive treatments for HCC such as resection or biliary drainage may be beneficial therapeutic options for patients with preserved liver function. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Association for the Study of the Liver | - |
dc.title | Clinical features and outcomes of patients with hepatocellular carcinoma complicated with bile duct invasion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Ji hyun | - |
dc.identifier.doi | 10.3350/cmh.2016.0088 | - |
dc.identifier.scopusid | 2-s2.0-85050579299 | - |
dc.identifier.wosid | 000407836000010 | - |
dc.identifier.bibliographicCitation | Clinical and molecular hepatology, v.23, no.2, pp.160 - 169 | - |
dc.relation.isPartOf | Clinical and molecular hepatology | - |
dc.citation.title | Clinical and molecular hepatology | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 160 | - |
dc.citation.endPage | 169 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.identifier.kciid | ART002231731 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | OBSTRUCTIVE-JAUNDICE SECONDARY | - |
dc.subject.keywordPlus | BILIARY OBSTRUCTION | - |
dc.subject.keywordPlus | TUMOR THROMBI | - |
dc.subject.keywordPlus | CLINICOPATHOLOGICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | SURGICAL OUTCOMES | - |
dc.subject.keywordPlus | METALLIC STENTS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DRAINAGE | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Bile duct invasion | - |
dc.subject.keywordAuthor | Treatment | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Obstructive jaundice | - |
dc.identifier.url | https://www.e-cmh.org/journal/view.php?doi=10.3350/cmh.2016.0088 | - |
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