REVISED DEFINITION OF PREDICTED LEFT VENTRICULAR MASS USING AMBULATORY BLOOD PRESSURE IN HEALTHY KOREAN ADULTS

Abstract

Objective: The left ventricular is known to be influenced by both hemodynamic and non-hemodynamic factors. Body size and gender are the most representative non-hemodynamic factors. This study was performed to establish the influences of these variables on the variation of the left ventricular mass in healthy Korean adults.

Design and Method: 487 subjects (male = 196, female = 291), with a normal body mass index and blood pressure, were included in the analysis form database of the Yangpyung Epidemiologic cohort.. The left ventricular mass was calculated using the equation: [1.04 × (IVSd + LVDd + PWTd)3-(LDVs3)] × 0.8 + 0.6. The stroke volume was calculated (mL/beat) using Teichholz's formula. The stroke work (SW in gram-meters/beat [g-m/beat]) was computed as ambulatory systolic BP × stroke volume × 0.0144.

Results: The stroke work (SW) was the most important factor associated with the LV mass (adjusted R2 = 0.499, p < 0.001), Height (m2.7), and sex were independent factors (adjusted R2 = 0.540). In a regression model, including stroke work, sex and height2.7, the LV mass was predicted by the equation: 39.55 + 6.58 × height (m2.7) + 0.70 × SW (g-m/beat)-10.64 × sex (male = 1, female = 2)(constant = 39.55 ± 15.03 g, adjusted R2 = 0.540, p = 0.001).

Conclusions: In this study using ambulatory BP, as with the previous studies, the stroke work, sex and height2.7 were important determinants of the left ventricular mass in Korean adults with a normal weight and normal blood pressure.