CARDIOVASCULAR RISK (CV) IN PRE-DIABETES AND DIABETES IN KOREA ASSESSED BY FRAMINGHAM RISK SCORE

Abstract

Objective: We aim to have a comprehensive overview of CV risks in diabetes and pre-diabetes in Korea.

Design and Method: This study was a nationwide, multicenter, non-interventional study on 10 general hospitals from November 2013 to June 2014. Multiple linear regressions were performed to investigate relationship between Framingham Risk Score (FRS) and CV risk factors (Myocardial Infarction, stroke, history of CV revascularization, history of angina, left ventricular hypertrophy (LVH), coronary artery stenosis >50%, carotid stenosis >50%).

Results: The final analysis was conducted with 1,537 patients with diabetes (N = 512) and pre-diabetes (N = 1,025). Male/female diabetic patients had higher FRS compared with pre-diabetic patients. Interestingly, FRS of male pre-diabetic patients was comparable with female diabetic patients (13.80 ± 7.37 and 13.35 ± 7.13, respectively). In multiple-regression analysis, history of angina was the most influential factor on CV risks in diabetes which increased FRS by 4.57 ± 2.09 (p = 0.0298), whereas history of LVH increased FRS by 9.68 ± 4.18 (p = 0.0209) in pre-diabetes. According to BMI status, FRS increased as BMI increased. Interestingly, J curve shape was noted in diabetic patients at BMI < 18.5, where FRS score increased.

Conclusions: Basically, the result showed that male FRS was higher than FRS of women. This study has provided information on overall distributions and characteristics of CV risk in pre-diabetes and diabetes, which is expected to serve as basic data for the establishment of measures to prevent and manage CV complication.