Detailed Information

Cited 18 time in webofscience Cited 26 time in scopus
Metadata Downloads

Evaluation of vitamin status in patients with pulmonary tuberculosis

Full metadata record
DC Field Value Language
dc.contributor.authorOh, Jongwon-
dc.contributor.authorChoi, Rihwa-
dc.contributor.authorPark, Hyung-Doo-
dc.contributor.authorLee, Hyun-
dc.contributor.authorJeong, Byeong-Ho-
dc.contributor.authorPark, Hye Yun-
dc.contributor.authorJeon, Kyeongman-
dc.contributor.authorKwon, O. Jung-
dc.contributor.authorKoh, Won-Jung-
dc.contributor.authorLee, Soo-Youn-
dc.date.accessioned2021-07-30T05:12:20Z-
dc.date.available2021-07-30T05:12:20Z-
dc.date.created2021-05-14-
dc.date.issued2017-03-
dc.identifier.issn0163-4453-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3564-
dc.description.abstractObjective Vitamins are known to be associated with immunity and nutrition. Moreover, vitamin deficiency can affect host immunity to various infectious diseases, including tuberculosis. Although patients with tuberculosis often have vitamin D deficiency, little is known about the levels of other vitamins. Here, we aimed to investigate the status of vitamins A, B12, D, and E in patients with tuberculosis. We also aimed to investigate the clinical and laboratory variables related to vitamin status in patients with tuberculosis. Methods We performed a case-control study to investigate the serum vitamin concentrations in 152 patients with tuberculosis and 137 control subjects. The concentrations of vitamin A, vitamin D, vitamin E, homocysteine, and methylmalonic acid were measured using high-performance liquid chromatography (HPLC) or HPLC-tandem mass spectrometry. Patient demographic data and other biochemical parameters were also analyzed. Results The serum concentrations of vitamins A, D, and E were significantly lower in patients with tuberculosis than in control subjects (1.4 vs. 2.0 μmol/L, P < 0.001; 10.6 vs. 19.3 ng/mL, P < 0.001; and 22.8 vs. 30.6 μmol/L, P < 0.001, respectively). In contrast, the methylmalonic acid levels were higher in patients with tuberculosis (134.9 vs. 110.8 nmol/L, P < 0.001). The prevalences of vitamin deficiencies were significantly higher in patients with tuberculosis. Moreover, multiple vitamin deficiencies were only observed in patients with tuberculosis (22.4% of all patients with tuberculosis vs. 0% of all control subjects). Positive correlations among vitamin A, D, and E concentrations were observed (vitamins A and D, r = 0.395; vitamins D and E, r = 0.342; and vitamins A and E, r = 0.427, P < 0.001). Body mass index, total cholesterol, low-density lipoprotein, iron, and total iron-binding capacity all showed positive correlations with vitamin A, D, and E concentrations. Conclusions Vitamin deficiencies are common in patients with tuberculosis. Further research investigating the clinical importance of vitamin and nutritional status in patients with tuberculosis is needed.-
dc.language영어-
dc.language.isoen-
dc.publisherW B SAUNDERS CO LTD-
dc.titleEvaluation of vitamin status in patients with pulmonary tuberculosis-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Hyun-
dc.identifier.doi10.1016/j.jinf.2016.10.009-
dc.identifier.scopusid2-s2.0-85007357769-
dc.identifier.wosid000397263200006-
dc.identifier.bibliographicCitationJOURNAL OF INFECTION, v.74, no.3, pp.272 - 280-
dc.relation.isPartOfJOURNAL OF INFECTION-
dc.citation.titleJOURNAL OF INFECTION-
dc.citation.volume74-
dc.citation.number3-
dc.citation.startPage272-
dc.citation.endPage280-
dc.type.rimsART-
dc.type.docType정기학술지(Article(Perspective Article포함))-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaInfectious Diseases-
dc.relation.journalWebOfScienceCategoryInfectious Diseases-
dc.subject.keywordPlusD DEFICIENCY-
dc.subject.keywordPlusINFECTIOUS-DISEASES-
dc.subject.keywordPlusACID-
dc.subject.keywordPlusNUTRITION-
dc.subject.keywordPlusASSOCIATION-
dc.subject.keywordPlusPOPULATION-
dc.subject.keywordPlusPREVALENCE-
dc.subject.keywordPlusIRON-
dc.subject.keywordAuthorNutrition-
dc.subject.keywordAuthorTuberculosis-
dc.subject.keywordAuthorVitamin-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0163445316302808?via%3Dihub-
Files in This Item
Go to Link
Appears in
Collections
서울 의과대학 > 서울 내과학교실 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Hyun photo

Lee, Hyun
COLLEGE OF MEDICINE (DEPARTMENT OF INTERNAL MEDICINE)
Read more

Altmetrics

Total Views & Downloads

BROWSE