CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms
DC Field | Value | Language |
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dc.contributor.author | Lee, Hong Kyung | - |
dc.contributor.author | Kim, Hyung Sook | - |
dc.contributor.author | Kim, Ji Sung | - |
dc.contributor.author | Kim, Yong Guk | - |
dc.contributor.author | Park, Ki Hwan | - |
dc.contributor.author | Lee, Jae Hee | - |
dc.contributor.author | Kim, Ki Hun | - |
dc.contributor.author | Chang, In Young | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.contributor.author | Hong, Jin Tae | - |
dc.contributor.author | Kehrl, John H. | - |
dc.contributor.author | Han, Sang-Bae | - |
dc.date.accessioned | 2021-07-30T05:12:34Z | - |
dc.date.available | 2021-07-30T05:12:34Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/3620 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characterized by autoantibody production. Mesenchymal stem cells (MSCs) ameliorate SLE symptoms by targeting T cells, whereas the mechanisms of their efficacy remain incompletely understood. In this study, we show that transfer of human MSCs increased MRL.Fas(lpr) mouse survival, decreased T cell infiltration in the kidneys, and reduced T cell cytokine expression. In vitro, allogeneic mouse MSCs inhibited MRL.Fas(lpr) T cell proliferation and cytokine production. Time-lapse imaging revealed that MSCs recruited MRL.Fas(lpr) T cells establishing long-lasting cellular contacts by enhancing T cell VCAM-1 expression in a CCL2-dependent manner. In contrast, CCL2 deficient MSCs did not induce T cell migration and VCAM-1 expression, resulting in insufficient cell-cell contact. Consequently, CCL2 deficient MSCs did not inhibit IFN-gamma production by T cells and upon transfer no longer prolonged survival of MRL.Fas(lpr) mice. Taken together, our imaging study demonstrates that CCL2 enables the prolonged MSC-T cell interactions needed for sufficient suppression of autoreactive T cells and helps to understand how MSCs ameliorate symptoms in lupus-prone MRL.Fas(lpr) mice. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1038/srep41258 | - |
dc.identifier.scopusid | 2-s2.0-85010715422 | - |
dc.identifier.wosid | 000393200000001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | LYMPH-NODES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | MRL/LPR | - |
dc.subject.keywordPlus | ERYTHEMATOSUS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.identifier.url | https://www.nature.com/articles/srep41258 | - |
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