Influence of Susceptible HLA-DRB1 Alleles on Clinical Subphenotypes of Systemic Lupus Erythematosus in Koreans
DC Field | Value | Language |
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dc.contributor.author | Bang, So-Young | - |
dc.contributor.author | Choi, Ji-Young | - |
dc.contributor.author | Park, Songree | - |
dc.contributor.author | Lee, Seung | - |
dc.contributor.author | Choi, Jeongim | - |
dc.contributor.author | Hong, Seung-Jae | - |
dc.contributor.author | Lee, Hye-Soon | - |
dc.contributor.author | Choi, Chan-Bum | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2021-08-03T06:59:17Z | - |
dc.date.available | 2021-08-03T06:59:17Z | - |
dc.date.created | 2021-07-23 | - |
dc.date.issued | 2015-11-08 | - |
dc.identifier.issn | 2326-5191 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/38304 | - |
dc.description.abstract | Background/Purpose: We investigated the association between human leukocyte antigen (HLA)-DRB1 alleles and systemic lupus erythematosus (SLE) susceptibility and whether each allele has a significant effect on clinical manifestations and autoantibody profiles in a Korean population. Methods: All SLE patients (n=1,089) and control subjects (n=2,161) were Korean. We performed a two-stage analysis in a discovery set (group 1: 475 SLE and 1,119 controls) and a replication set (group 2: 614 SLE and 1,072 controls) using high-resolution HLA-DRB1 typing. The odds ratio (OR) of risk alleles associated with SLE was calculated by a regression method, which was adjusted for age, sex, and disease duration. Results: We found that four HLA-DRB1 alleles [two confirmed alleles; *15:01 (P=1.11×10-13), *09:01 (P=1.59×10-5), two novel alleles; *08:03 (P=8.80×10-8), *07:01 (P=1.14×10-6)] and were associated with susceptibility to SLE. Double copies of these risk alleles (OR 3.38) were associated with a higher risk of developing SLE than a single copy (OR 1.95), showing additive genetic effects. In addition, three novel HLA-DRB1*12:02 (P=6.35×10-4), *11:01 (P=1.24×10-3), *13:02 (P=8.88×10-3) alleles were significantly protective against SLE. The HLA-DRB1*15:01 allele alone (OR 2.20) and double-copies of risk alleles (OR 3.71) increased the risk for anti-Sm production. In addition, SLE patients with double-copies of risk alleles showed more diverse clinical manifestations. Conclusion: We demonstrated that four HLA–DRB1 risk alleles were associated with SLE in a Korean population, and also promote the production of anti-Sm and diverse clinical manifestations | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Influence of Susceptible HLA-DRB1 Alleles on Clinical Subphenotypes of Systemic Lupus Erythematosus in Koreans | - |
dc.type | Conference | - |
dc.contributor.affiliatedAuthor | Bang, So-Young | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Soon | - |
dc.contributor.affiliatedAuthor | Choi, Chan-Bum | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.wosid | 000370860201088 | - |
dc.identifier.bibliographicCitation | 2015 ACR/ARHP Annual Meeting | - |
dc.relation.isPartOf | 2015 ACR/ARHP Annual Meeting | - |
dc.relation.isPartOf | ARTHRITIS & RHEUMATOLOGY | - |
dc.citation.title | 2015 ACR/ARHP Annual Meeting | - |
dc.citation.conferencePlace | US | - |
dc.citation.conferencePlace | San Francisco, CA. | - |
dc.citation.conferenceDate | 2015-11-06 | - |
dc.type.rims | CONF | - |
dc.description.journalClass | 1 | - |
dc.identifier.url | https://acrabstracts.org/abstract/influence-of-susceptible-hla-drb1-alleles-on-clinical-subphenotypes-of-systemic-lupus-erythematosus-in-koreans/ | - |
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