Outcomes after Discontinuing Tumor Necrosis Factor Inhibitor in Rheumatoid Arthritis: 2 Years of 'post-Golimumab' after Completion of the 5-Year Extension Study in Korea
DC Field | Value | Language |
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dc.contributor.author | Shin, Kichul | - |
dc.contributor.author | Kwon, Hyun Mi | - |
dc.contributor.author | Kang, Seong-Wook | - |
dc.contributor.author | Park, Won | - |
dc.contributor.author | Park, Sung-Hwan | - |
dc.contributor.author | Suh, Chang-Hee | - |
dc.contributor.author | Kim, Hyun Ah | - |
dc.contributor.author | Lee, Seung-Geun | - |
dc.contributor.author | Lee, Choong Ki | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Soo-Kon | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.date.accessioned | 2021-08-03T06:59:28Z | - |
dc.date.available | 2021-08-03T06:59:28Z | - |
dc.date.created | 2021-07-23 | - |
dc.date.issued | 2015-11-08 | - |
dc.identifier.issn | 2326-5191 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/38307 | - |
dc.description.abstract | Background/Purpose: Tumor necrosis factor inhibitors (TNFi) have helped patients achieve remarkable outcomes as in improving synovitis and halting structural damages in severe cases of rheumatoid arthritis (RA). Nowadays academic interests lie towards strategies of ‘tapering’ or ‘discontinuing’ biological therapy, especially in cases where patients are being maintained in clinical remission for an adequate period. However, not many studies have traced the outcomes after discontinuing TNFi. Methods: The ‘Investigation of outcomes after Golimumab discontinuation’ or GOLD study, is an observational study participated by 10 centers nationwide, following up clinical data of Korean RA patients who were enrolled in the 5-year extension study of GO-BEFORE and GO-FORWARD. Medical records of the 2-year post-golimumab period were reviewed and pertinent clinical data including DAS scores, prescriptions, comorbidities, laboratory findings, as well as radiographic images were analyzed. Results: The 60 RA patients (male 5, female 55) had the following mean values at discontinuation (baseline); age of 51.0 years, disease duration of 16.5 years, and a DAS28-CRP score of 2.71. At the 2-year time point, 9/60 (15%) patients had restarted biologics. The mean period restarting biologics was 18.7 months (range 4~28) after discontinuation. Baseline characteristics of the ‘biologic restarters’ and ‘non-biologic users’ are depicted in the table. New joint damage was discovered only in non-biologic users (4/51 patients) at 2 years. Conclusion: The GOLD study based on ‘deliberate’ discontinuation of TNFi in RA patients with low disease activity shows that patients with higher swollen joint counts, physician’s global assessment score at the time point of discontinuation tend to restart biologics in the near future. New joint damage ensued only in those off biologics. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Outcomes after Discontinuing Tumor Necrosis Factor Inhibitor in Rheumatoid Arthritis: 2 Years of 'post-Golimumab' after Completion of the 5-Year Extension Study in Korea | - |
dc.type | Conference | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.wosid | 000370860201580 | - |
dc.identifier.bibliographicCitation | 2015 ACR/ARHP Annual Meeting | - |
dc.relation.isPartOf | 2015 ACR/ARHP Annual Meeting | - |
dc.relation.isPartOf | ARTHRITIS & RHEUMATOLOGY | - |
dc.citation.title | 2015 ACR/ARHP Annual Meeting | - |
dc.citation.conferencePlace | US | - |
dc.citation.conferencePlace | San Francisco, CA. | - |
dc.citation.conferenceDate | 2015-11-06 | - |
dc.type.rims | CONF | - |
dc.description.journalClass | 1 | - |
dc.identifier.url | https://acrabstracts.org/abstract/outcomes-after-discontinuing-tumor-necrosis-factor-inhibitor-in-rheumatoid-arthritis-2-years-of-post-golimumab-after-completion-of-the-5-year-extension-study-in-korea/ | - |
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