Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Sung Wook | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Im, Jong Pil | - |
dc.contributor.author | Ye, Byong Duk | - |
dc.contributor.author | Koo, Hoon Sup | - |
dc.contributor.author | Huh, Kyu Chan | - |
dc.contributor.author | Cheon, Jae Hee | - |
dc.contributor.author | Kim, You Sun | - |
dc.contributor.author | Kim, Young Ho | - |
dc.contributor.author | Han, Dong Soo | - |
dc.contributor.author | Kim, Won Ho | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.date.accessioned | 2021-07-30T05:18:09Z | - |
dc.date.available | 2021-07-30T05:18:09Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4047 | - |
dc.description.abstract | Background and Aim The present study evaluated the clinical characteristics of Korean patients with Crohn's disease (CD) according to their age at diagnosis in a nationwide multicenter cohort study. Methods A total of 1224 patients diagnosed with CD between 1982 and 2008 in 32 hospitals were included, and age at diagnosis was categorized as ≤ 16 (G1), 17–40 (G2), 41–59 (G3) and ≥ 60 (G4) years old. The baseline characteristics, medication, and intestinal resection were compared according to the age at diagnosis. Results The number of patients in each age group was 155 (G1; 12.7%), 919 (G2; 75.1%), 120 (G3; 9.8%), and 30 (G4; 2.5%). The frequencies of ileocolonic disease in the late adult onset and elderly onset groups were lower than those in the other groups (P < 0.001). The cumulative probabilities of thiopurine and anti-tumor necrosis factor use in late adult onset and elderly onset groups were significantly reduced compared with those of the other groups (P < 0.01). However, the risk of the first intestinal resection was not different among the age groups. The ileal location (hazard ratio [HR]: 1.59; 95% confidence interval [CI]: 1.11–2.27), complicated behavior (HR: 3.35; 95% CI: 2.63–4.27), and early thiopurine use (HR: 0.27; 95% CI: 0.17–0.43) were associated with the first intestinal resection, whereas the age at diagnosis was not a risk factor. Conclusions Elderly onset CD may be related to favorable outcomes in Korea. Thus, the heterogeneity of this disease should be considered when developing a tailored strategy for the treatment of CD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Dong Soo | - |
dc.identifier.doi | 10.1111/jgh.13775 | - |
dc.identifier.scopusid | 2-s2.0-85029923945 | - |
dc.identifier.wosid | 000411724400012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.32, no.10, pp.1716 - 1722 | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1716 | - |
dc.citation.endPage | 1722 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | LONG-TERM PROGNOSIS | - |
dc.subject.keywordPlus | MONTREAL CLASSIFICATION | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordAuthor | age at diagnosis | - |
dc.subject.keywordAuthor | Crohn&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | intestinal resection | - |
dc.subject.keywordAuthor | medication | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/jgh.13775 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.