New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial
DC Field | Value | Language |
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dc.contributor.author | Jeong, Jae Yoon | - |
dc.contributor.author | Sohn, Joo Hyun | - |
dc.contributor.author | Baek, Yang Hyun | - |
dc.contributor.author | Cho, Yong Kyun | - |
dc.contributor.author | Kim, Yongsoo | - |
dc.contributor.author | Kim, Hyeonjin | - |
dc.date.accessioned | 2021-07-30T05:18:23Z | - |
dc.date.available | 2021-07-30T05:18:23Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4111 | - |
dc.description.abstract | AIM To evaluate the efficacy and safety of HL tablet extracted from magnolia officinalis for treating patients with nonalcoholic fatty liver disease (NAFLD). METHODS Seventy-four patients with NAFLD diagnosed by ultrasonography were randomly assigned to 3 groups given high dose (400 mg) HL tablet, low dose (133.4 mg) HL tablet and placebo, respectively, daily for 12 wk. The primary endpoint was post-treatment change of hepatic fat content (HFC) measured by magnetic resonance spectroscopy. Secondary endpoints included changes of serum aspartate aminotransferase, alanine aminotransferase (ALT), cholesterol, triglyceride, free fatty acid, homeostasis model assessment-estimated insulin resistance, and body mass index (BMI). RESULTS The mean HFC of the high dose HL group, but not of the low dose group, declined significantly after 12 wk of treatment (high dose vs placebo, P = 0.033; low dose vs placebo, P = 0.386). The mean changes of HFC from baseline at week 12 were -1.7% ± 3.1% in the high dose group (P = 0.018), -1.21% ± 4.97% in the low dose group (P = 0.254) and 0.61% ± 3.87% in the placebo group (relative changes compared to baseline, high dose were: -12.1% ± 23.5%, low dose: -3.2% ± 32.0%, and placebo: 7.6% ± 44.0%). Serum ALT levels also tended to decrease in the groups receiving HL tablet while other factors were unaffected. There were no moderate or severe treatment-related safety issues during the study. CONCLUSION HL tablet is effective in reducing HFC without any negative lipid profiles, BMI changes and adverse effects. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.title | New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sohn, Joo Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Yongsoo | - |
dc.identifier.doi | 10.3748/wjg.v23.i32.5977 | - |
dc.identifier.scopusid | 2-s2.0-85028623428 | - |
dc.identifier.wosid | 000408603500016 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.23, no.32, pp.5977 - 5985 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 32 | - |
dc.citation.startPage | 5977 | - |
dc.citation.endPage | 5985 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | LIFE-STYLE MODIFICATION | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | OBETICHOLIC ACID | - |
dc.subject.keywordPlus | BLADDER-CANCER | - |
dc.subject.keywordPlus | STEATOHEPATITIS | - |
dc.subject.keywordPlus | PIOGLITAZONE | - |
dc.subject.keywordPlus | HONOKIOL | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | THIAZOLIDINEDIONES | - |
dc.subject.keywordPlus | HEPATOCYTES | - |
dc.subject.keywordAuthor | Botanical drug | - |
dc.subject.keywordAuthor | Nonalcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Magnetic resonance spectroscopy | - |
dc.subject.keywordAuthor | Randomized controlled trial | - |
dc.subject.keywordAuthor | Magnolia officinali | - |
dc.identifier.url | https://www.wjgnet.com/1007-9327/full/v23/i32/5977.htm | - |
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