Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정복기 | - |
dc.contributor.author | 이원재 | - |
dc.contributor.author | 강은혜 | - |
dc.contributor.author | 안효민 | - |
dc.contributor.author | 김용욱 | - |
dc.contributor.author | 나동균 | - |
dc.contributor.author | 윤채옥 | - |
dc.contributor.author | 윤인식 | - |
dc.date.accessioned | 2021-07-30T05:19:46Z | - |
dc.date.available | 2021-07-30T05:19:46Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 2287-1152 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4263 | - |
dc.description.abstract | Background: Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. Methods: Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. Results: Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. Conclusion: Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한두개안면성형외과학회 | - |
dc.title | Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 윤채옥 | - |
dc.identifier.doi | 10.7181/acfs.2017.18.1.9 | - |
dc.identifier.bibliographicCitation | Archives of Craniofacial Surgery, v.18, no.1, pp.9 - 15 | - |
dc.relation.isPartOf | Archives of Craniofacial Surgery | - |
dc.citation.title | Archives of Craniofacial Surgery | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 15 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002206518 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordAuthor | Gene therapy | - |
dc.subject.keywordAuthor | Cicatrix | - |
dc.subject.keywordAuthor | Relaxin | - |
dc.subject.keywordAuthor | Adenovirus | - |
dc.identifier.url | https://e-acfs.org/journal/view.php?doi=10.7181/acfs.2017.18.1.9 | - |
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