Biological applications of zinc imidazole framework through protein encapsulation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, Pawan | - |
dc.contributor.author | Bansal, Vasudha | - |
dc.contributor.author | Paul,Albish K. | - |
dc.contributor.author | Bharadwaj, Lalit M. | - |
dc.contributor.author | Deep, Akash | - |
dc.contributor.author | Kim, Ki-Hyun | - |
dc.date.accessioned | 2021-07-30T05:21:23Z | - |
dc.date.available | 2021-07-30T05:21:23Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 2190-5509 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4359 | - |
dc.description.abstract | The robustness of biomolecules is always a significant challenge in the application of biostorage in biotechnology or pharmaceutical research. To learn more about biostorage in porous materials, we investigated the feasibility of using zeolite imidazolate framework (ZIF-8) with respect to protein encapsulation. Here, bovine serum albumin (BSA) was selected as a model protein for encapsulation with the synthesis of ZIF-8 using water as a media. ZIF-8 exhibited excellent protein adsorption capacity through successive adsorption of free BSA with the formation of hollow crystals. The loading of protein in ZIF-8 crystals is affected by the molecular weight due to diffusion-limited permeation inside the crystals and also by the affinity of the protein to the pendent group on the ZIF-8 surface. The polar nature of BSA not only supported adsorption on the solid surface, but also enhanced the affinity of crystal spheres through weak coordination interactions with the ZIF-8 framework. The novel approach tested in this study was therefore successful in achieving protein encapsulation with porous, biocompatible, and decomposable microcrystalline ZIF-8. The presence of both BSA and FITC-BSA in ZIF-8 was confirmed consistently by spectroscopy as well as optical and electron microscopy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.title | Biological applications of zinc imidazole framework through protein encapsulation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ki-Hyun | - |
dc.identifier.doi | 10.1007/s13204-015-0511-x | - |
dc.identifier.scopusid | 2-s2.0-85041601714 | - |
dc.identifier.wosid | 000393372000001 | - |
dc.identifier.bibliographicCitation | APPLIED NANOSCIENCE, v.6, no.7, pp.951 - 957 | - |
dc.relation.isPartOf | APPLIED NANOSCIENCE | - |
dc.citation.title | APPLIED NANOSCIENCE | - |
dc.citation.volume | 6 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 951 | - |
dc.citation.endPage | 957 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.subject.keywordPlus | METAL-ORGANIC FRAMEWORKS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | ZIF-8 | - |
dc.subject.keywordAuthor | Zeolitic imidazolate framework (ZIF-8) | - |
dc.subject.keywordAuthor | Proteins | - |
dc.subject.keywordAuthor | BSA | - |
dc.subject.keywordAuthor | Successive adsorption | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs13204-015-0511-x | - |
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