Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
DC Field | Value | Language |
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dc.contributor.author | Yun, In Sik | - |
dc.contributor.author | Kang, Eunhye | - |
dc.contributor.author | Ahn, Hyo Min | - |
dc.contributor.author | Kim, Yong Oock | - |
dc.contributor.author | Rah, Dong Kyun | - |
dc.contributor.author | Roh, Tai Suk | - |
dc.contributor.author | Lee, Won Jai | - |
dc.contributor.author | Yun, Chae-Ok | - |
dc.date.accessioned | 2021-07-30T05:23:00Z | - |
dc.date.available | 2021-07-30T05:23:00Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4540 | - |
dc.description.abstract | Purpose: Relaxin (RLX) is a transforming growth factor-beta 1 (TGF-beta 1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads) are accepted vectors for cancer gene therapy. However, repeated treatments of Ad are limited by short-term biological activity in vivo. The efficacy of sustained RLX expression to scar remodeling was assessed using an injectable alginate gel-matrix system. Materials and Methods: Pig scar tissue was treated with relaxin-expressing Ad loaded in alginate gel (gel/Ad-RLX). Surface areas, color, and pliability of scars were compared, and various factors influencing scar formation and collagen arrangement were analyzed. Results: Gel/Ad-RLX decreased scar size, color index, and pliability. Immunohistochemistry showed decreased levels of major extracellular matrix proteins in the gel/Ad-RLX-treated group. Furthermore, treatment with gel/Ad-RLX reduced expression of tissue inhibitor of metalloproteinase-1 and alpha-smooth muscle actin and markedly increased expression of matrix metalloproteinase-1 in pig scar tissues. Gel/Ad-RLX also significantly downregulated TGF-beta 1 and upregulated TGF-beta 3 mRNAs in pig scar tissues. Conclusion: These results support a prominent role for RLX in scar remodeling and suggest that gel/Ad-RLX may have therapeutic effects on scar formation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.title | Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yun, Chae-Ok | - |
dc.identifier.doi | 10.3349/ymj.2019.60.9.854 | - |
dc.identifier.scopusid | 2-s2.0-85071758921 | - |
dc.identifier.wosid | 000486548500006 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.60, no.9, pp.854 - 863 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 60 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 854 | - |
dc.citation.endPage | 863 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002492476 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | ONCOLYTIC ADENOVIRUS | - |
dc.subject.keywordPlus | RAT WOUNDS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | PORCINE | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | HORMONE | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Gene therapy | - |
dc.subject.keywordAuthor | scar remodeling | - |
dc.subject.keywordAuthor | relaxin | - |
dc.subject.keywordAuthor | adenovirus | - |
dc.subject.keywordAuthor | alginate gel | - |
dc.subject.keywordAuthor | pig scar model | - |
dc.identifier.url | https://eymj.org/DOIx.php?id=10.3349/ymj.2019.60.9.854 | - |
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