RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahee | - |
dc.contributor.author | Choi, Eunji | - |
dc.contributor.author | Lee, Jaewon | - |
dc.contributor.author | Oh, Jungju | - |
dc.contributor.author | Lee, Seonyeong | - |
dc.contributor.author | Lee, Minhyung | - |
dc.date.accessioned | 2021-07-30T05:24:31Z | - |
dc.date.available | 2021-07-30T05:24:31Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4660 | - |
dc.description.abstract | Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Minhyung | - |
dc.identifier.doi | 10.1016/j.jiec.2018.06.040 | - |
dc.identifier.scopusid | 2-s2.0-85049756457 | - |
dc.identifier.wosid | 000448095700027 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.67, pp.284 - 292 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 67 | - |
dc.citation.startPage | 284 | - |
dc.citation.endPage | 292 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002405700 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | BOX | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | HMGB1 | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordAuthor | Anti-angiogenesis | - |
dc.subject.keywordAuthor | Gene delivery | - |
dc.subject.keywordAuthor | Glioblastoma | - |
dc.subject.keywordAuthor | Polyethylenimine | - |
dc.subject.keywordAuthor | RAGE-binding peptide | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1226086X18303319?via%3Dihub | - |
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