Agglomeration of human dermal fibroblasts with ECM mimicking nano-fragments and their effects on proliferation and cell/ECM interactions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahmad, Taufiq | - |
dc.contributor.author | Shin, Young Min | - |
dc.contributor.author | Lee, Jinkyu | - |
dc.contributor.author | Shin, Hyeok Jun | - |
dc.contributor.author | Perikamana, Sajeesh Kumar Madhurakart | - |
dc.contributor.author | Shin, Heungsoo | - |
dc.date.accessioned | 2021-07-30T05:24:31Z | - |
dc.date.available | 2021-07-30T05:24:31Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4661 | - |
dc.description.abstract | Here, we engineered spheroids by using ECM mimicking nano-fragments (NFs) with fibroblasts and investigated their effect on proliferation and cell/ECM interactions. NF incorporation resulted in formation of a stable spheroid, which improved proliferation and viability of cells by assisting oxygen transport confirmed by LOX-1 staining. In addition, hypoxic and apoptotic genes were significantly downregulated in spheroids with PD-NFs. Furthermore, ECM and cell junction proteins were highly expressed. Overall, our findings suggest that incorporation of NFs within spheroids for assembly with various cell types can be an alternative approach for 3D cell culture in many applications. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Agglomeration of human dermal fibroblasts with ECM mimicking nano-fragments and their effects on proliferation and cell/ECM interactions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Heungsoo | - |
dc.identifier.doi | 10.1016/j.jiec.2018.06.017 | - |
dc.identifier.scopusid | 2-s2.0-85049428385 | - |
dc.identifier.wosid | 000448095700006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.67, pp.80 - 91 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 67 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 91 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002405679 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | REGENERATIVE MEDICINE | - |
dc.subject.keywordPlus | CULTURE SYSTEMS | - |
dc.subject.keywordPlus | DRUG DISCOVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | 3D | - |
dc.subject.keywordPlus | SPHEROIDS | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordAuthor | Nano-fragment (NF) | - |
dc.subject.keywordAuthor | NF-spheroids | - |
dc.subject.keywordAuthor | Hybrid spheroids | - |
dc.subject.keywordAuthor | Composite spheroid | - |
dc.subject.keywordAuthor | 3D culture | - |
dc.subject.keywordAuthor | Polydopamine | - |
dc.subject.keywordAuthor | ECM | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1226086X18303071?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.