Inducing angiogenesis with the controlled release of nitric oxide from biodegradable and biocompatible copolymeric nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Yang, Chungmo | - |
dc.contributor.author | Hwang, Hae Hyun | - |
dc.contributor.author | Jeong, Soohyun | - |
dc.contributor.author | Seo, Deokwon | - |
dc.contributor.author | Jeong, Yoon | - |
dc.contributor.author | Lee, Dong Yun | - |
dc.contributor.author | Lee, Kangwon | - |
dc.date.accessioned | 2021-07-30T05:24:32Z | - |
dc.date.available | 2021-07-30T05:24:32Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4667 | - |
dc.description.abstract | Purpose: Nitric oxide (NO) can be clinically applied at low concentrations to regulate angiogenesis. However, studies using small molecule NO donors (N-diazeniumdiolate, S-nitrosothiol, etc) have yet to meet clinical requirements due to the short half-life and initial burst-release profile of NO donors. In this study, we report the feasibility of methoxy poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) (mPEG-PLGA) nanoparticles (NPs) as NO-releasing polymers (NO-NPs) for inducing angiogenesis. Materials and methods: The mPEG-PLGA copolymers were synthesized by typical ring-opening polymerization of lactide, glycolide and mPEG as macroinitiators. Double emulsion methods were used to prepare mPEG-PLGA NPs incorporating hydrophilic NONOate (diethylenetriamine NONOate). Results: This liposomal NP encapsulates hydrophilic diethylenetriamine NONOate (70%+/- 4%) more effectively than other previously reported materials. The application of NO-NPs at different ratios resulted in varying NO-release profiles with no significant cytotoxicity in various cell types: normal cells (fibroblasts, human umbilical vein endothelial cells and epithelial cells) and cancer cells (C6, A549 and MCF-7). The angiogenic potential of NO-NPs was confirmed in vitro by tube formation and ex vivo through an aorta ring assay. Tubular formation increased 189.8% in NO-NP-treated groups compared with that in the control group. Rat aorta exhibited robust sprouting angiogenesis in response to NO-NPs, indicating that NO was produced by polymeric NPs in a sustained manner. Conclusion: These findings provide initial results for an angiogenesis-related drug development platform by a straightforward method with biocompatible polymers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | Inducing angiogenesis with the controlled release of nitric oxide from biodegradable and biocompatible copolymeric nanoparticles | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong Yun | - |
dc.identifier.doi | 10.2147/IJN.S174989 | - |
dc.identifier.scopusid | 2-s2.0-85056276705 | - |
dc.identifier.wosid | 000447520500004 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.13, pp.6517 - 6530 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 13 | - |
dc.citation.startPage | 6517 | - |
dc.citation.endPage | 6530 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CORE-SHELL NANOPARTICLES | - |
dc.subject.keywordPlus | PEG-PLGA COPOLYMERS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | POLYMERSOMES | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | mPEG-PLGA nanoparticles | - |
dc.subject.keywordAuthor | sprouting angiogenesis | - |
dc.subject.keywordAuthor | low concentration of nitric oxide | - |
dc.subject.keywordAuthor | liposomal nanoparticles | - |
dc.subject.keywordAuthor | amphiphilic polymers | - |
dc.identifier.url | https://www.dovepress.com/inducing-angiogenesis-with-the-controlled-release-of-nitric-oxide-from-peer-reviewed-fulltext-article-IJN | - |
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