Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ullah, Irfan | - |
dc.contributor.author | Chung, Kunho | - |
dc.contributor.author | Oh, Jungju | - |
dc.contributor.author | Beloor, Jagadish | - |
dc.contributor.author | Bae, Sumin | - |
dc.contributor.author | Lee, Sangah Clara | - |
dc.contributor.author | Lee, Minhyung | - |
dc.contributor.author | Kumar, Priti | - |
dc.contributor.author | Lee, Sang-Kyung | - |
dc.date.accessioned | 2021-07-30T05:24:33Z | - |
dc.date.available | 2021-07-30T05:24:33Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4673 | - |
dc.description.abstract | Ischemic stroke-induced neuronal cell death results in the permanent disabling of brain function. Apoptotic mechanisms are thought to play a prominent role in neuronal injury and ample evidence implicates Fas signaling in mediating cell death. In this study, we describe the neuroprotective effects of a Fas-blocking peptide (FBP) that by obstructing Fas signaling in cerebral ischemia inhibits apoptosis. Using an intranasal administration route in a rat model of focal cerebral ischemia, we demonstrate that nose-to-brain delivery of FBP after middle cerebral artery occlusion (MCAO) surgery results in the delivery and retention of FBP in Fas-expressing ischemic areas of the brain. A single intranasal administration of 2 mg/kg FBP resulted in significantly reduced neuronal cell death by inhibiting Fas-mediated apoptosis leading to decreased infarct volumes, reduced neurologic deficit scores and recovery from cerebral ischemia. Intranasally delivered FBP might be a promising strategy for the treatment of cerebral ischemic stroke. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Minhyung | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Kyung | - |
dc.identifier.doi | 10.1038/s41598-018-33296-z | - |
dc.identifier.scopusid | 2-s2.0-85054777279 | - |
dc.identifier.wosid | 000446803100005 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NASAL DRUG-DELIVERY | - |
dc.subject.keywordPlus | GLUCOSE-TRANSPORTER | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | SIRNA | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.identifier.url | https://www.nature.com/articles/s41598-018-33296-z | - |
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