Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus
DC Field | Value | Language |
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dc.contributor.author | Beloor, Jagadish | - |
dc.contributor.author | Maes, Nyree | - |
dc.contributor.author | Ullah, Irfan | - |
dc.contributor.author | Uchil, Pradeep | - |
dc.contributor.author | Jackson, Andrew | - |
dc.contributor.author | Fikrig, Erol | - |
dc.contributor.author | Lee, Sang Kyung | - |
dc.contributor.author | Kumar, Priti | - |
dc.date.accessioned | 2021-07-30T05:24:41Z | - |
dc.date.available | 2021-07-30T05:24:41Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4717 | - |
dc.description.abstract | No vaccines or therapeutics are licensed for West Nile virus (WNV), a mosquito-transmitted neuroencephalitic flavivirus. The small interfering RNA siFvE(JW) targets a conserved sequence within the WNV E protein and limits virus infection. Using a rabies virusderived neuron-targeting peptide (RVG9R) and an intranasal route for delivering siFvE(JW) to the CNS, we demonstrate that treatment of WNV-infected mice at late stages of neuroinvasive disease results in recovery. Selectively targeting virus in the CNS lowers viral burdens in the brain, reduces neuropathology, and results in a 90% survival rate at 5-6 days post-infection (when viral titers peak in the CNS), while placebo-treated mice succumb by days 9-10. Importantly, CNS virus clearance is achieved by humoral and cell-mediated immune responses to WNV infection in peripheral tissues, which also engender sterilizing immunity against subsequent WNV infection. These results indicate that intranasal RVG9R-siRNA treatment offers efficient late-stage therapy and facilitates natural long-term immunity against neuroinvasive flaviviruses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kyung | - |
dc.identifier.doi | 10.1016/j.chom.2018.03.001 | - |
dc.identifier.scopusid | 2-s2.0-85044007802 | - |
dc.identifier.wosid | 000429927100015 | - |
dc.identifier.bibliographicCitation | CELL HOST & MICROBE, v.23, no.4, pp.549 - 561 | - |
dc.relation.isPartOf | CELL HOST & MICROBE | - |
dc.citation.title | CELL HOST & MICROBE | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 549 | - |
dc.citation.endPage | 561 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | HUMANIZED MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | INTRANASAL DELIVERY | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | ENCEPHALITIS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordAuthor | CNS delivery | - |
dc.subject.keywordAuthor | flavivirus | - |
dc.subject.keywordAuthor | intranasal treatment | - |
dc.subject.keywordAuthor | natural immunity | - |
dc.subject.keywordAuthor | rabies virus glycoprotein | - |
dc.subject.keywordAuthor | siRNA | - |
dc.subject.keywordAuthor | therapeutics | - |
dc.subject.keywordAuthor | West Nile virus | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1931312818300982?via%3Dihub | - |
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