Senotherapy for attenuation of cellular senescence in aging and organ implantation

Abstract

Cellular senescence in transplant is induced by aging and therapy-induced stress, which is caused by generation of senescent cells in transplant during engraftment. These senescent cells induce transplant failure due to secretion of senescence-associated secretory phenotype (SASP). So, elimination of senescent cells in transplant is important for successful comes. Recently, numerous studies have focused on the development of various senolytic agents such as dasatinib, quercetin, and navitoclax according to cellular type of transplant. Therefore, this study reviews the influence of cellular senescence in transplantation and capacity of senolytic agents as a new therapeutic strategy for successful outcomes of transplant. (C) 2017 The Korean Society of Industrial and Engineering Chemistry.