Gene delivery to pancreatic islets for effective transplantation in diabetic animal
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Minhyung | - |
dc.contributor.author | Kim, Min Jun | - |
dc.contributor.author | Oh, Jungju | - |
dc.contributor.author | Piao, Chunxian | - |
dc.contributor.author | Park, Young-Woo | - |
dc.contributor.author | Lee, Dong Yun | - |
dc.date.accessioned | 2021-07-30T05:24:50Z | - |
dc.date.available | 2021-07-30T05:24:50Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4758 | - |
dc.description.abstract | Pancreas islet transplantation is a promising approach to cure diabetes mellitus. However, transplanted islets are easily damaged by hypoxic microenvironment and immunosuppressive agents. Cytoprotective gene delivery into islets could overcome those challenges by expressing the transferred therapeutic genes. In this circumstance, several factors need to be considered for genetic modification of pancreas islets. First, safe and efficient gene delivery tools should be developed. Second, effective therapeutic genes with few side-effects should be developed. Furthermore, strong gene regulation and expression systems are required. Therefore, we here review various gene-carriers and therapeutic genes for genetic engineering of pancreatic islets ex vivo. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Gene delivery to pancreatic islets for effective transplantation in diabetic animal | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Minhyung | - |
dc.contributor.affiliatedAuthor | Lee, Dong Yun | - |
dc.identifier.doi | 10.1016/j.jiec.2017.07.038 | - |
dc.identifier.scopusid | 2-s2.0-85028343748 | - |
dc.identifier.wosid | 000414815800003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.56, pp.45 - 54 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 56 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 54 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002291875 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | GLUCAGON-LIKE PEPTIDE-1 | - |
dc.subject.keywordPlus | SECRETION SIGNAL PEPTIDE | - |
dc.subject.keywordPlus | GROWTH-FACTOR-I | - |
dc.subject.keywordPlus | BETA-CELL DESTRUCTION | - |
dc.subject.keywordPlus | INDUCIBLE VEGF GENE | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | GRAFT-SURVIVAL | - |
dc.subject.keywordPlus | AUTOIMMUNE INSULITIS | - |
dc.subject.keywordPlus | MEDIATED DYSFUNCTION | - |
dc.subject.keywordPlus | ADENOVIRUS VECTOR | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Pancreatic islets transplantation | - |
dc.subject.keywordAuthor | Gene delivery | - |
dc.subject.keywordAuthor | Therapeutic genes | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1226086X17304124?via%3Dihub | - |
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