Development of fluorescence-conjugated islet-homing peptide using biopanning for targeted optical imaging of pancreatic islet
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Min Jun | - |
dc.contributor.author | Yu, Jeong Heon | - |
dc.contributor.author | Oh, Mi Hwa | - |
dc.contributor.author | Nam, Yoon Sung | - |
dc.contributor.author | Lee, Dong Yun | - |
dc.date.accessioned | 2021-07-30T05:26:03Z | - |
dc.date.available | 2021-07-30T05:26:03Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4839 | - |
dc.description.abstract | Visualization of pancreatic islet can provide important information for diagnosis and monitoring of pancreatic islets. By using phage display technology, here we newly identified four candidate peptide sequences with islet-homing property. In vitro binding assay showed that LSALPRT peptide had stronger affinity with islet cells than other candidates. Then this islet-homing peptide (IHP) was chemically conjugated with TAMRA fluorophore for near infrared (NIR) imaging of islet cells. This TMARA-IHP was strongly bound to islets in vitro, but also to cryo-sectioned slice of pancreas tissue ex vivo. Collectively, it would be a considerable potential as therapeutics or diagnostics in future studies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Development of fluorescence-conjugated islet-homing peptide using biopanning for targeted optical imaging of pancreatic islet | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong Yun | - |
dc.identifier.doi | 10.1016/j.jiec.2016.10.009 | - |
dc.identifier.scopusid | 2-s2.0-84998962589 | - |
dc.identifier.wosid | 000391647600051 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.45, pp.404 - 411 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 45 | - |
dc.citation.startPage | 404 | - |
dc.citation.endPage | 411 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002192049 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | PHAGE DISPLAY | - |
dc.subject.keywordPlus | BETA-CELL | - |
dc.subject.keywordPlus | TRANSPLANTED ISLETS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordAuthor | Islet-homing peptide | - |
dc.subject.keywordAuthor | Pancreatic islet | - |
dc.subject.keywordAuthor | Phage display | - |
dc.subject.keywordAuthor | Biopanning | - |
dc.subject.keywordAuthor | Islet imaging | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1226086X16303884?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.