The Role of Mast Cells in Irritable Bowel Syndrome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kang Nyeong | - |
dc.contributor.author | Lee, Oh Young | - |
dc.date.accessioned | 2021-07-30T05:26:09Z | - |
dc.date.available | 2021-07-30T05:26:09Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1687-6121 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4864 | - |
dc.description.abstract | Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, but its treatment is unsatisfactory as its pathophysiology is multifactorial. The putative factors of IBS pathophysiology are visceral hypersensitivity and intestinal dysmotility, also including psychological factors, dysregulated gut-brain axis, intestinal microbiota alterations, impaired intestinal permeability, and mucosal immune alterations. Recently, mucosal immune alterations have received much attention with the role of mast cells in IBS. Mast cells are abundant in the intestines and function as intestinal gatekeepers at the interface between the luminal environment in the intestine and the internal milieu under the intestinal epithelium. As a gatekeeper at the interface, mast cells communicate with the adjacent cells such as epithelial, neuronal, and other immune cells throughout the mediators released when they themselves are activated. Many studies have suggested that mast cells play a role in the pathophysiology of IBS. This review will focus on studies of the role of mast cell in IBS and the limitations of studies and will also consider future directions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.title | The Role of Mast Cells in Irritable Bowel Syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kang Nyeong | - |
dc.contributor.affiliatedAuthor | Lee, Oh Young | - |
dc.identifier.doi | 10.1155/2016/2031480 | - |
dc.identifier.scopusid | 2-s2.0-85009499850 | - |
dc.identifier.wosid | 000391999900001 | - |
dc.identifier.bibliographicCitation | GASTROENTEROLOGY RESEARCH AND PRACTICE, v.2016, pp.1 - 11 | - |
dc.relation.isPartOf | GASTROENTEROLOGY RESEARCH AND PRACTICE | - |
dc.citation.title | GASTROENTEROLOGY RESEARCH AND PRACTICE | - |
dc.citation.volume | 2016 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | INTESTINAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | DIARRHEA-PREDOMINANT IBS | - |
dc.subject.keywordPlus | MUCOSAL IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | VISCERAL HYPERSENSITIVITY | - |
dc.subject.keywordPlus | BARRIER DYSFUNCTION | - |
dc.subject.keywordPlus | ABDOMINAL-PAIN | - |
dc.subject.keywordPlus | GASTROINTESTINAL SYMPTOMS | - |
dc.subject.keywordPlus | INCREASED PERMEABILITY | - |
dc.subject.keywordPlus | SUBSTANCE-P | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.identifier.url | https://www.hindawi.com/journals/grp/2016/2031480/ | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.