A New Electrolytic Synthesis Method for Few-Layered MoS2 Nanosheets and Their Robust Biointerfacing with Reduced Antibodies
DC Field | Value | Language |
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dc.contributor.author | Kukkar, Manil | - |
dc.contributor.author | Tuteja, Satish K. | - |
dc.contributor.author | Sharma, Amit L. | - |
dc.contributor.author | Kumar, Vinod | - |
dc.contributor.author | Paul, Ashok K. | - |
dc.contributor.author | Kim, Ki-Hyun | - |
dc.contributor.author | Sabherwal, Priyanka | - |
dc.contributor.author | Deep, Akash | - |
dc.date.accessioned | 2021-07-30T05:28:16Z | - |
dc.date.available | 2021-07-30T05:28:16Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5009 | - |
dc.description.abstract | We report an efficient method for the synthesis of few-layered MoS2 nanosheets and demonstrate their application in the label-free detection of the prostate-specific antigen (PSA) cancer marker. As a novel strategy, the electro-dissolution of molybdenum metal sheets in the presence of Na+ and S2- ions led to the formation of Na+ intercalated MoS2. Further exfoliation by ultrasonication yielded the desired formation of few-layered MoS2 nanosheets. After comprehensive characterization, the synthesized MoS2 nanosheets were channeled in a field-effect transistor (FET) microdevice. Chemically reduced anti-PSA antibodies were immobilized on the MoS2 channel above the FET microdevice to construct a specific PSA immunosensor. The antibodies were deliberately reduced to expose the hinge-region disulfide bonds. This approach offered a robust and site-directed immunosensing device through biointerfacing of the sulfhydryl groups (SH) in the reduced antibody with the surface S atoms of MoS2. This device was validated as an effective immunosensor with a low detection limit (10(-5)ng/mL) over a wide linear detection range (10(-5) to 75 ng/mL). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | A New Electrolytic Synthesis Method for Few-Layered MoS2 Nanosheets and Their Robust Biointerfacing with Reduced Antibodies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ki-Hyun | - |
dc.identifier.doi | 10.1021/acsami.6b03079 | - |
dc.identifier.scopusid | 2-s2.0-84977631562 | - |
dc.identifier.wosid | 000379456000004 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.8, no.26, pp.16555 - 16563 | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 8 | - |
dc.citation.number | 26 | - |
dc.citation.startPage | 16555 | - |
dc.citation.endPage | 16563 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | EFFICIENT EXFOLIATION | - |
dc.subject.keywordPlus | LITHIUM INTERCALATION | - |
dc.subject.keywordPlus | SENSITIVE DETECTION | - |
dc.subject.keywordPlus | LIQUID EXFOLIATION | - |
dc.subject.keywordPlus | GRAPHENE | - |
dc.subject.keywordPlus | MONOLAYER | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | WS2 | - |
dc.subject.keywordAuthor | few-layered nanosheets | - |
dc.subject.keywordAuthor | MoS2 | - |
dc.subject.keywordAuthor | reduced antibody | - |
dc.subject.keywordAuthor | immunosensor | - |
dc.subject.keywordAuthor | prostate-specific antigen | - |
dc.subject.keywordAuthor | FET | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsami.6b03079 | - |
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