Local Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shen, Guang-Yin | - |
dc.contributor.author | Park, In-Hwa | - |
dc.contributor.author | Song, Yi-Sun | - |
dc.contributor.author | Joo, Hyun-Woo | - |
dc.contributor.author | Lee, Yonggu | - |
dc.contributor.author | Shin, Jeong-Hun | - |
dc.contributor.author | Kim, Kyung-Soo | - |
dc.contributor.author | Kim, Hyuck | - |
dc.date.accessioned | 2021-07-30T05:28:22Z | - |
dc.date.available | 2021-07-30T05:28:22Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5038 | - |
dc.description.abstract | A systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat model. A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. The local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | - |
dc.title | Local Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Jeong-Hun | - |
dc.contributor.affiliatedAuthor | Kim, Hyuck | - |
dc.identifier.doi | 10.1007/s13770-016-9054-9 | - |
dc.identifier.scopusid | 2-s2.0-84973377000 | - |
dc.identifier.wosid | 000377468200011 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.13, no.3, pp.297 - 303 | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.title | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 297 | - |
dc.citation.endPage | 303 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002112166 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | G-CSF | - |
dc.subject.keywordPlus | CELL MOBILIZATION | - |
dc.subject.keywordPlus | CARDIAC-FUNCTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | CARDIOMYOCYTES | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordAuthor | Granulocyte-colony stimulating factor | - |
dc.subject.keywordAuthor | Wound healing | - |
dc.subject.keywordAuthor | Local injection | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.