Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2021-07-30T05:28:31Z | - |
dc.date.available | 2021-07-30T05:28:31Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 0770-3198 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5074 | - |
dc.description.abstract | The objective of the study was to determine by meta-analysis whether polymorphisms of the gene encoding peptidylarginine deiminase 4 (PADI4) are associated with susceptibility to rheumatoid arthritis (RA). A literature review was conducted to identify data sets that described analyses of genetic association between PADI4 polymorphisms and RA. Data sets were collated and a meta-analysis was performed, with a specific focus on associations within Caucasian and Asian populations. A total of 15,947 RA cases and 22,696 controls that were taken from 28 studies in 24 papers were included in this study. Meta-analysis showed a significant association between allele 2 of the PADI4_94 polymorphism and RA in the overall population (odds ratio [OR] = 1.155, 95 % confidence interval [CI] = 1.069-1.249, p = 2.7 x 10⁻⁵). Stratification by ethnicity revealed an association between PADI4_94 allele 2 and RA in Asians (OR = 1.273, 95 % CI = 1.193-1.359, p < 1.0 x 10⁻⁹), but not in Caucasians (OR = 1.024, 95 % CI = 0.973-1.078, p = 0.358). However, meta-analysis using homozygote contrast showed an association between PADI4_94 allele 2 and RA in both Asians (OR = 2.311, 95 % CI = 1.1.858-2.875, p < 1.0 x 10⁻⁹) and Caucasians (OR = 1.523, 95 % CI = 1.157-2.004, p = 0.008). Meta-analysis also revealed an association between allele 2 of the PADI4_104 polymorphism and RA in both Asians (OR = 1.547, 95 % CI = 1.247-1.919, p = 7.1 x 10⁻⁶) and Caucasians (OR = 1.096, 95 % CI = 1.025-1.172, p = 0.008). Finally, meta-analysis showed an association between allele 2 of the PADI4_92 polymorphism and RA in Asians (OR = 1.263, 95 % CI = 1.153-1.384, p = 5.8 x 10⁻⁸), but not in Caucasians (OR = 1.123, 95 % CI = 0.980-1.287, p = 0.095). Meta-analysis indicated no association between allele 2 of either the PADI4_90 or PADI4_89 polymorphisms and RA in Asians. This meta-analysis revealed that the PADI4_94 and PADI_104 polymorphisms are associated with susceptibility to RA in Asians and Caucasians, and that the PADI4_92 polymorphism is associated with susceptibility to RA in Asians, but not in Caucasians. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER LONDON LTD | - |
dc.title | Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1007/s10067-015-3098-4 | - |
dc.identifier.scopusid | 2-s2.0-84945208589 | - |
dc.identifier.wosid | 000373155800017 | - |
dc.identifier.bibliographicCitation | CLINICAL RHEUMATOLOGY, v.35, no.4, pp.961 - 971 | - |
dc.relation.isPartOf | CLINICAL RHEUMATOLOGY | - |
dc.citation.title | CLINICAL RHEUMATOLOGY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 961 | - |
dc.citation.endPage | 971 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | FUNCTIONAL HAPLOTYPE | - |
dc.subject.keywordPlus | CITRULLINATED PEPTIDE | - |
dc.subject.keywordPlus | JAPANESE POPULATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | CHINESE | - |
dc.subject.keywordPlus | PTPN22 | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | PADI4 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10067-015-3098-4 | - |
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