Outcome of Inhaler Withdrawal in Patients Receiving Triple Therapy for COPD
DC Field | Value | Language |
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dc.contributor.author | Kim, Sae Ahm | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Kim, Eun-Kyung | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Kim, Woo Jin | - |
dc.contributor.author | Lee, Jin Hwa | - |
dc.contributor.author | Yoon, Ho Il | - |
dc.contributor.author | Baek, Seunghee | - |
dc.contributor.author | Lee, Jae Seung | - |
dc.contributor.author | Oh, Yeon-Mok | - |
dc.contributor.author | Lee, Sang-Do | - |
dc.date.accessioned | 2021-07-30T05:30:10Z | - |
dc.date.available | 2021-07-30T05:30:10Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5148 | - |
dc.description.abstract | Background: The purpose of this study was to document outcomes following withdrawal of a single inhaler (step-down) in chronic obstructive pulmonary disease (COPD) patients on triple therapy (long-acting muscarinic antagonist and a combination of long-acting beta 2-agonists and inhaled corticosteroid), which a common treatment strategy in clinical practice. Methods: Through a retrospective observational study, COPD patients receiving triple therapy over 2 years (triple group; n=109) were compared with those who had undergone triple therapy for at least 1 year and subsequently, over 9 months, initiated inhaler withdrawal (step-down group, n=39). The index time was defined as the time of withdrawal in the step-down group and as 1 year after the start of triple therapy in the triple group. Results: Lung function at the index time was superior and the previous exacerbation frequency was lower in the step-down group than in the triple group. Step-down resulted in aggravating disease symptoms, a reduced overall quality of life, decreasing exercise performance, and accelerated forced expiratory volume in 1 second (FEV1) decline (54.7 +/- 15.7 mL/yr vs. 10.7 +/- 7.1 mL/yr, p=0.007), but there was no observed increase in the frequency of exacerbations. Conclusion: Withdrawal of a single inhaler during triple therapy in COPD patients should be conducted with caution as it may impair the exercise capacity and quality of life while accelerating FEV1 decline. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAEHAN KYORHAEK HYOPHOE-KOREAN ACAD TUBERCULOSIS & RESPIRATORY DISEASES | - |
dc.title | Outcome of Inhaler Withdrawal in Patients Receiving Triple Therapy for COPD | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hyung | - |
dc.identifier.doi | 10.4046/trd.2016.79.1.22 | - |
dc.identifier.scopusid | 2-s2.0-85011805294 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS AND RESPIRATORY DISEASES, v.79, no.1, pp.22 - 30 | - |
dc.relation.isPartOf | TUBERCULOSIS AND RESPIRATORY DISEASES | - |
dc.citation.title | TUBERCULOSIS AND RESPIRATORY DISEASES | - |
dc.citation.volume | 79 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 22 | - |
dc.citation.endPage | 30 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002127694 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject.keywordPlus | AIR-FLOW OBSTRUCTION | - |
dc.subject.keywordPlus | FLUTICASONE PROPIONATE | - |
dc.subject.keywordPlus | CORTICOSTEROIDS | - |
dc.subject.keywordPlus | TIOTROPIUM | - |
dc.subject.keywordPlus | SALMETEROL | - |
dc.subject.keywordPlus | EXACERBATIONS | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | FORMOTEROL | - |
dc.subject.keywordPlus | PLACEBO | - |
dc.subject.keywordAuthor | Pulmonary Disease | - |
dc.subject.keywordAuthor | Chronic Obstructive | - |
dc.identifier.url | https://www.e-trd.org/journal/view.php?doi=10.4046/trd.2016.79.1.22 | - |
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