Synthesis and cellular affinity of a water-soluble sulfated diselenide compound as a H2O2-responsive ionic cross-linker
DC Field | Value | Language |
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dc.contributor.author | Lee, Eunsun | - |
dc.contributor.author | Park, Hyo-chan | - |
dc.contributor.author | Lee, Dongwon | - |
dc.contributor.author | Park, Sang Jun | - |
dc.contributor.author | Kim, Yong-Hee | - |
dc.contributor.author | Kim, Chun-Ho | - |
dc.date.accessioned | 2021-07-30T05:31:18Z | - |
dc.date.available | 2021-07-30T05:31:18Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5174 | - |
dc.description.abstract | Because various stimuli can affect living organisms, substances that response to stimuli, such as H2O2, have been studied for biomaterials. To synthesize a biocompatible H2O2-responsive ionic cross-linker, we synthesized a water-soluble H2O2-responsive diselenide compounds containing both sulfate end groups (diSe-SO4). The synthesis of diSe-SO4 was evaluated by H-1 NMR and FT-IR. H2O2 responsiveness was evaluated by UV-vis spectra, FT-IR, and XPS. The optical density at 303 nm due to diselenide in diSe-SO4 was decreased in the H2O2 concentration increased. FT-IR and XPS results showed new peaks at 880 cm and 3500 cm(-1), and at 63.0 eV, respectively, due to oxidized Se, which indicated the cleavage of the diselenide bond in diSe-SO4 as the H2O2 concentration increased. The ionic binding efficiency of diSe-SO4 to cationic materials was confirmed by measuring the zeta-potential difference (from -15.6 mV to 10.3 mV) before and after mixing with chitosan. MRC-5 cell viability and apoptosis in the presence of diSe-SO4 was evaluated using a CCK-8 assay and FACS, respectively. A high cell viability exceeding 95% was observed at 500 mu M diSe-SO4 over 48 h of culture. In conclusion, the synthesized water-soluble diSe-SO4 provides a H2O2-responsive ionic cross-linking material with a high cell affinity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Synthesis and cellular affinity of a water-soluble sulfated diselenide compound as a H2O2-responsive ionic cross-linker | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Hee | - |
dc.identifier.doi | 10.1016/j.jiec.2019.11.026 | - |
dc.identifier.scopusid | 2-s2.0-85076238921 | - |
dc.identifier.wosid | 000514214400020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.83, pp.181 - 188 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 83 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 188 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002568652 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | COPOLYMER | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | GELATION | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordAuthor | H2O2-responsive | - |
dc.subject.keywordAuthor | Stimuli-responsive | - |
dc.subject.keywordAuthor | Water-soluble | - |
dc.subject.keywordAuthor | Diselenide | - |
dc.subject.keywordAuthor | Ionic interaction | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1226086X19306185?via%3Dihub | - |
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