Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative-lipid complex
DC Field | Value | Language |
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dc.contributor.author | Jha, Saurav Kumar | - |
dc.contributor.author | Han, Hee-Soo | - |
dc.contributor.author | Subedi, Laxman | - |
dc.contributor.author | Pangeni, Rudra | - |
dc.contributor.author | Chung, Jee Young | - |
dc.contributor.author | Kweon, Seho | - |
dc.contributor.author | Choi, Jeong Uk | - |
dc.contributor.author | Byun, Youngro | - |
dc.contributor.author | Kim, Yong-Hee | - |
dc.contributor.author | Park, Jin Woo | - |
dc.date.accessioned | 2021-07-30T05:31:18Z | - |
dc.date.available | 2021-07-30T05:31:18Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1071-7544 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5176 | - |
dc.description.abstract | In this study, a system for oral delivery of etoposide (ETP) was designed to avoid the problems associated with low and variable bioavailability of a commercially available ETP emulsion comprised of polyethylene glycol, glycerol, and citric acid anhydrous. ETP was complexed with low-molecular-weight methylcellulose (ETP/LMC) and loaded into a water-in-oil-in-water multiple nanoemulsion to formulate an ETP/LMC-nanoemulsion (ELNE). To further enhance the oral bioavailability, an ionic complex formed by anionic lipid 1,2-didecanoyl-sn-glycero-3-phosphate (sodium salt) and cationic N (alpha)-deoxycholyl-l-lysyl-methylester was incorporated into ELNE, yielding ELNE#7. As expected, ELNE#7 showed 4.07- and 2.25-fold increases in artificial membrane and Caco-2/HT29-MTX-E12 permeability (P-app ), respectively, resulting in 224% greater oral bioavailability compared with the commercially available ETP emulsion. In contrast, inhibition of clathrin- and caveola-mediated endocytosis, macropinocytosis, and bile acid transporters by chlorpromazine, genistein, amiloride, and actinomycin D in Caco-2/HT-29-MTX-E12 monolayers reduced the P-app by 45.0%, 20.5%, 28.8%, and 31.1%, respectively. These findings suggest that these routes play important roles in enhancing the oral absorption of ELNE#7. In addition, our mechanistic study suggested that P-glycoprotein did not have an inhibitory effect on the permeation of ELNE#7. Notably, ELNE#7 showed significantly enhanced toxicity in LLC and A549 cells compared with ETP-E. These observations support the improved oral absorption of ETP in ELNE#7, suggesting that it is a better alternative than ETP emulsion. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative-lipid complex | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Hee | - |
dc.identifier.doi | 10.1080/10717544.2020.1837293 | - |
dc.identifier.scopusid | 2-s2.0-85094844707 | - |
dc.identifier.wosid | 000582684000001 | - |
dc.identifier.bibliographicCitation | DRUG DELIVERY, v.27, no.1, pp.1501 - 1513 | - |
dc.relation.isPartOf | DRUG DELIVERY | - |
dc.citation.title | DRUG DELIVERY | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1501 | - |
dc.citation.endPage | 1513 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | INTESTINAL-ABSORPTION | - |
dc.subject.keywordPlus | DELIVERY-SYSTEMS | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | CYCLOSPORINE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | CARRIER | - |
dc.subject.keywordAuthor | Etoposide | - |
dc.subject.keywordAuthor | nanoemulsion | - |
dc.subject.keywordAuthor | permeability | - |
dc.subject.keywordAuthor | oral bioavailability | - |
dc.subject.keywordAuthor | bile acid transporter-mediated uptake | - |
dc.subject.keywordAuthor | oral absorption | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/10717544.2020.1837293 | - |
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