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In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Park, Hanseul | - |
| dc.contributor.author | Oh, Jungju | - |
| dc.contributor.author | Shim, Gayong | - |
| dc.contributor.author | Cho, Byounggook | - |
| dc.contributor.author | Chang, Yujung | - |
| dc.contributor.author | Kim, Siyoung | - |
| dc.contributor.author | Baek, Soonbong | - |
| dc.contributor.author | Kim, Hongwon | - |
| dc.contributor.author | Shin, Jeain | - |
| dc.contributor.author | Choi, Hwan | - |
| dc.contributor.author | Yoo, Junsang | - |
| dc.contributor.author | Kim, Junyeop | - |
| dc.contributor.author | Jun, Won | - |
| dc.contributor.author | Lee, Minhyung | - |
| dc.contributor.author | Lengner, Christopher J. | - |
| dc.contributor.author | Oh, Yu-Kyoung | - |
| dc.contributor.author | Kim, Jongpil | - |
| dc.date.accessioned | 2021-07-30T05:31:26Z | - |
| dc.date.available | 2021-07-30T05:31:26Z | - |
| dc.date.created | 2021-05-11 | - |
| dc.date.issued | 2019-04 | - |
| dc.identifier.issn | 1097-6256 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5219 | - |
| dc.description.abstract | In vivo gene editing in post-mitotic neurons of the adult brain may be a useful strategy for treating neurological diseases. Here, we develop CRISPR-Cas9 nanocomplexes and show they were effective in the adult mouse brain, with minimal off-target effects. Using this system to target Bacel suppressed amyloid beta (A beta)-associated pathologies and cognitive deficits in two mouse models of Alzheimer's disease. These results broaden the potential application of CRISPR-Cas9 systems to neurodegenerative diseases. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | NATURE PUBLISHING GROUP | - |
| dc.title | In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Lee, Minhyung | - |
| dc.identifier.doi | 10.1038/s41593-019-0352-0 | - |
| dc.identifier.scopusid | 2-s2.0-85062819266 | - |
| dc.identifier.wosid | 000462154300006 | - |
| dc.identifier.bibliographicCitation | NATURE NEUROSCIENCE, v.22, no.4, pp.524 - 528 | - |
| dc.relation.isPartOf | NATURE NEUROSCIENCE | - |
| dc.citation.title | NATURE NEUROSCIENCE | - |
| dc.citation.volume | 22 | - |
| dc.citation.number | 4 | - |
| dc.citation.startPage | 524 | - |
| dc.citation.endPage | 528 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Neurosciences & Neurology | - |
| dc.relation.journalWebOfScienceCategory | Neurosciences | - |
| dc.subject.keywordPlus | MICE | - |
| dc.subject.keywordPlus | EXPRESSION | - |
| dc.subject.keywordPlus | PROTEIN | - |
| dc.subject.keywordPlus | MUSCLE | - |
| dc.identifier.url | https://www.nature.com/articles/s41593-019-0352-0 | - |
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Related Researcher
- Lee, Min hyung
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)