Enhancement of T2-weighted MR contrast using heparin for cell tracking in vivo
DC Field | Value | Language |
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dc.contributor.author | Hwang, Y.H. | - |
dc.contributor.author | Jeong, M.J. | - |
dc.contributor.author | Kim, M.J. | - |
dc.contributor.author | Kim, J.K. | - |
dc.contributor.author | Lee, D.Y. | - |
dc.date.accessioned | 2021-07-30T05:31:56Z | - |
dc.date.available | 2021-07-30T05:31:56Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5365 | - |
dc.description.abstract | Superparamagnetic iron oxide (SPIO) nanoparticle has emerged as a novel probe for noninvasively cellular tracking using magnetic resonance imaging. Here we developed SPIO nanoparticles coated with biocompatible heparins, i.e., low-molecular-weight-heparin (LMWH) or unfractionated heparin (UFH). These heparin-SPIO nanoparticles showed good crystallizability and stability without self-aggregation for 50 days. Also, UFH-SPIO nanoparticle had lower relaxation time with higher relaxivity. Moreover, they were efficiently internalized into cells without cytotoxicity and had faster saturated magnetization. Furthermore, the implanted SPIO nanoparticles-labeled Ins-1 cells were strongly visualized in vivo MR imaging. Collectively, heparin-based SPIO nanoparticles could have a great potential for in vivo cellular tracking. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society of Industrial Engineering Chemistry | - |
dc.title | Enhancement of T2-weighted MR contrast using heparin for cell tracking in vivo | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, D.Y. | - |
dc.identifier.doi | 10.1016/j.jiec.2017.06.043 | - |
dc.identifier.scopusid | 2-s2.0-85022059847 | - |
dc.identifier.wosid | 000408788500018 | - |
dc.identifier.bibliographicCitation | Journal of Industrial and Engineering Chemistry, v.55, pp.183 - 190 | - |
dc.relation.isPartOf | Journal of Industrial and Engineering Chemistry | - |
dc.citation.title | Journal of Industrial and Engineering Chemistry | - |
dc.citation.volume | 55 | - |
dc.citation.startPage | 183 | - |
dc.citation.endPage | 190 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002283774 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | Biocompatibility | - |
dc.subject.keywordPlus | Cells | - |
dc.subject.keywordPlus | Cytology | - |
dc.subject.keywordPlus | Iron oxides | - |
dc.subject.keywordPlus | Magnetic resonance imaging | - |
dc.subject.keywordPlus | Nanomagnetics | - |
dc.subject.keywordPlus | Nanoparticles | - |
dc.subject.keywordPlus | Superparamagnetism | - |
dc.subject.keywordPlus | Cell transplantation | - |
dc.subject.keywordPlus | Crystallizability | - |
dc.subject.keywordPlus | Heparin | - |
dc.subject.keywordPlus | Low-molecular weight heparins | - |
dc.subject.keywordPlus | Saturated magnetization | - |
dc.subject.keywordPlus | Superparamagnetic iron oxide nanoparticles | - |
dc.subject.keywordPlus | Superparamagnetic iron oxides | - |
dc.subject.keywordPlus | Unfractionated heparins | - |
dc.subject.keywordPlus | Polysaccharides | - |
dc.subject.keywordAuthor | Cell transplantation | - |
dc.subject.keywordAuthor | Cellular tracking | - |
dc.subject.keywordAuthor | Heparin | - |
dc.subject.keywordAuthor | MRI | - |
dc.subject.keywordAuthor | Superparamagnetic iron oxide (SPIO) | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1226086X17303325?via%3Dihub | - |
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