Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy
DC Field | Value | Language |
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dc.contributor.author | Lee, DaeYong | - |
dc.contributor.author | Lee, Soo-Hwan | - |
dc.contributor.author | Na, Youjin | - |
dc.contributor.author | Noh, Ilkoo | - |
dc.contributor.author | Ha, JongHoon | - |
dc.contributor.author | Yoo, Jisang | - |
dc.contributor.author | Bang, Hyun Bae | - |
dc.contributor.author | Park, Jong Hyun | - |
dc.contributor.author | Jeong, Ki Jun | - |
dc.contributor.author | Yun, Chae-Ok | - |
dc.contributor.author | Kim, Yeu-Chun | - |
dc.date.accessioned | 2021-07-30T05:33:11Z | - |
dc.date.available | 2021-07-30T05:33:11Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5378 | - |
dc.description.abstract | Artificial cationic helical peptides possess an enhanced cell-penetrating property. However, their cell-penetrability is not converted by cellular environmental changes resulting in nonspecific uptake. In this study, pH-sensitive anion-donating groups were added to a helical polypeptide to simultaneously achieve tumor targeting and pro-apoptotic activity. The mitochondria-destabilizing helical polypeptide undergoing pH-dependent conformational transitions selectively targeted cancer cells consequently disrupting mitochondrial membranes and subsequently inducing apoptosis. This work presents a promising peptide therapeutic system for cancer therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yun, Chae-Ok | - |
dc.identifier.doi | 10.1016/j.jconrel.2017.08.001 | - |
dc.identifier.scopusid | 2-s2.0-85027857846 | - |
dc.identifier.wosid | 000412177500003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.264, pp.24 - 33 | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 264 | - |
dc.citation.startPage | 24 | - |
dc.citation.endPage | 33 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | ANTIMICROBIAL PEPTIDES | - |
dc.subject.keywordPlus | PENETRATION | - |
dc.subject.keywordAuthor | pH-activated helical formation | - |
dc.subject.keywordAuthor | Mitochondrial membrane destabilization | - |
dc.subject.keywordAuthor | Pro-apoptotic activity | - |
dc.subject.keywordAuthor | Cancer targeting and therapy | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S016836591730768X | - |
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