Enhanced Systemic Anti-Angiogenic siVEGF Delivery Using PEGylated Oligo-D-arginine
DC Field | Value | Language |
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dc.contributor.author | Chung, Jee Young | - |
dc.contributor.author | Ul Ain, Qurrat | - |
dc.contributor.author | Lee, Hyun Lin | - |
dc.contributor.author | Kim, So-Mi | - |
dc.contributor.author | Kim, Yong-Hee | - |
dc.date.accessioned | 2021-07-30T05:33:12Z | - |
dc.date.available | 2021-07-30T05:33:12Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1543-8384 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5382 | - |
dc.description.abstract | Angiogenesis mainly mediated by upregulation of vascular endothelial growth factor (VEGF) provides a hallmark of rapidly proliferating tumor cells and an essential component of the tumor growth and microenvironment, making it a targetable process for antitumor therapy. RNA interference (RNAi) provides a very effective tool for developing antitumor therapies; however, its application to date has been hampered due to the lack of efficient small interfering RNA (siRNA) delivery systems in vivo. Here, we report a polymeric gene carrier system based on PEGylation of a cationic cysteine-ended 9-mer arginine oligopeptide (CR9C), which provides effective siRNA systemic delivery and specifically suppresses VEGF (siVEGF). The PEG500-CR9C/siVEGF oligopeptoplex provided improved blood circulation, enhanced protection from serum proteases, reduced uptake in the liver and kidneys, enhanced tumor targeting, and down-regulated intratumoral VEGF level, which comprehensively resulted in improved antitumor efficacy without significant toxicity in vivo. PEG500-CR9C has a great potential for safe and efficient siRNA delivery with diverse applications. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Enhanced Systemic Anti-Angiogenic siVEGF Delivery Using PEGylated Oligo-D-arginine | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Hee | - |
dc.identifier.doi | 10.1021/acs.molpharmaceut.7b00282 | - |
dc.identifier.scopusid | 2-s2.0-85028817161 | - |
dc.identifier.wosid | 000410005100019 | - |
dc.identifier.bibliographicCitation | MOLECULAR PHARMACEUTICS, v.14, no.9, pp.3059 - 3068 | - |
dc.relation.isPartOf | MOLECULAR PHARMACEUTICS | - |
dc.citation.title | MOLECULAR PHARMACEUTICS | - |
dc.citation.volume | 14 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 3059 | - |
dc.citation.endPage | 3068 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SMALL-INTERFERING RNA | - |
dc.subject.keywordPlus | SIRNA DELIVERY | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CIRCULATION | - |
dc.subject.keywordPlus | POLYPLEXES | - |
dc.subject.keywordPlus | CARRIER | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | enhanced permeability and enhanced effect | - |
dc.subject.keywordAuthor | siVEGF delivery | - |
dc.subject.keywordAuthor | PEGylation | - |
dc.subject.keywordAuthor | antitumor therapy | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.7b00282 | - |
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