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Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles
- Authors
- Kim, Jin; Yang, Kisuk; Lee, Jong Seung; Hwang, Yong Hwa; Park, Hyun-Ji; Park, Kook In; Lee, Dong Yun; Cho, Seung-Woo
- Issue Date
- Aug-2017
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- differentiation; graphene oxide nanoparticle; neural stem cell; self-renewal
- Citation
- MACROMOLECULAR BIOSCIENCE, v.17, no.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 17
- Number
- 8
- ISSN
- 1616-5187
- Abstract
- Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GONP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis.
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Related Researcher
- Lee, Dong Yun
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)