The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Su Jin | - |
dc.contributor.author | Park, Soo-Heon | - |
dc.contributor.author | Moon, Jeong Seop | - |
dc.contributor.author | Shin, Woon Geon | - |
dc.contributor.author | Kim, Jae Gyu | - |
dc.contributor.author | Lee, Yong Chan | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Kim, Jae J. | - |
dc.contributor.author | Lee, Hang-Lak | - |
dc.contributor.author | Lee, Sang Woo | - |
dc.contributor.author | Hwangbo, Young | - |
dc.contributor.author | Xu, Jianming | - |
dc.contributor.author | Wang, Bangmao | - |
dc.contributor.author | Xue, Zhanxiong | - |
dc.contributor.author | Liu, Fei | - |
dc.contributor.author | Yuan, Yaozong | - |
dc.contributor.author | Leelakusolvong, Somchai | - |
dc.contributor.author | Dy, Frederick | - |
dc.date.accessioned | 2021-07-30T05:33:54Z | - |
dc.date.available | 2021-07-30T05:33:54Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5490 | - |
dc.description.abstract | Background/Aims To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. Methods A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. Results The mean decreases in the total symptom score at 4 weeks were estimated to be −18.1±13.8 in the combination therapy group and −15.1±11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were −8.4±6.6 in the combination therapy group and −6.8±5.9 in the monotherapy group (p=0.009). Conclusions Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.title | The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hang-Lak | - |
dc.identifier.doi | 10.5009/gnl15537 | - |
dc.identifier.scopusid | 2-s2.0-84992602775 | - |
dc.identifier.wosid | 000386644900010 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.10, no.6, pp.910 - 916 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 10 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 910 | - |
dc.citation.endPage | 916 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002164932 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | PROTON PUMP INHIBITOR | - |
dc.subject.keywordPlus | GASTROESOPHAGEAL-REFLUX | - |
dc.subject.keywordPlus | BARRETTS-ESOPHAGUS | - |
dc.subject.keywordPlus | EROSIVE ESOPHAGITIS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | BILE-ACIDS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | GASTRITIS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Peptic esophagitis | - |
dc.subject.keywordAuthor | Symptoms | - |
dc.subject.keywordAuthor | Heartburn | - |
dc.subject.keywordAuthor | Rebamipide | - |
dc.subject.keywordAuthor | Esomeprazole | - |
dc.identifier.url | https://www.gutnliver.org/journal/view.html?doi=10.5009/gnl15537 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.