Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Changhwan | - |
dc.contributor.author | Jung, Ji Ye | - |
dc.contributor.author | Kim, Young Sam | - |
dc.contributor.author | Lee, Jae Seung | - |
dc.contributor.author | Rhee, Chin Kook | - |
dc.contributor.author | Lee, Jin Hwa | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Lim, Seong Yong | - |
dc.contributor.author | Sheen, Seung Soo | - |
dc.contributor.author | Yoo, Kwang Ha | - |
dc.contributor.author | Seo, Joon Beom | - |
dc.contributor.author | Oh, Yeon-Mok | - |
dc.contributor.author | Lee, Sang-Do | - |
dc.contributor.author | Park, Yong Bum | - |
dc.date.accessioned | 2021-07-30T05:35:18Z | - |
dc.date.available | 2021-07-30T05:35:18Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5579 | - |
dc.description.abstract | Background: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. Objectives: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. Methods: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity ≥17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). Results: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). Conclusion: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.title | Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hyung | - |
dc.identifier.doi | 10.1159/000445266 | - |
dc.identifier.scopusid | 2-s2.0-84975256325 | - |
dc.identifier.wosid | 000377991300001 | - |
dc.identifier.bibliographicCitation | RESPIRATION, v.91, no.5, pp.351 - 358 | - |
dc.relation.isPartOf | RESPIRATION | - |
dc.citation.title | RESPIRATION | - |
dc.citation.volume | 91 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 351 | - |
dc.citation.endPage | 358 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | LUNG-FUNCTION | - |
dc.subject.keywordPlus | SYSTEMIC INFLAMMATION | - |
dc.subject.keywordPlus | MUSCLE FUNCTION | - |
dc.subject.keywordPlus | WALK DISTANCE | - |
dc.subject.keywordPlus | COPD | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordAuthor | Chronic obstructive pulmonary disease | - |
dc.subject.keywordAuthor | Vitamin D deficiency | - |
dc.subject.keywordAuthor | Exercise capacity | - |
dc.subject.keywordAuthor | Six-minute walk distance | - |
dc.identifier.url | https://www.karger.com/Article/FullText/445266 | - |
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