Drug Delivery Systems of Fusion Proteins for the Treatment of Ischemic Heart Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용희 | - |
dc.date.accessioned | 2021-08-03T21:36:25Z | - |
dc.date.available | 2021-08-03T21:36:25Z | - |
dc.date.created | 2021-06-30 | - |
dc.date.issued | 2009-06-17 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/61469 | - |
dc.description.abstract | We developed novel in situ gel depot drug delivery systems for the protein delivery, in which a physical in situ gel, not chemically cross-linked, was formed by adding two oppositely charged biomacromolecules and the resulting complex coacervates were furthermore co-formulated with a negative thermosensitive polysaccharide containing a salting-out salt. An optimized novel delivery system containing dual advantages of complex coacervation and temperature responsiveness demonstrated a potential for Hsp-PTD fusion protein delivery in terms of sustained release, less initial burst, and stability of proteins in vitro. The animal experiment using rat LAD ischemia/perfusion (I/R) model showed that both Hsp-PTD solutions administered systemically and Hsp-PTD loaded in situ gel were very effective in reducing infarct size caused by hypoxia insult and enhancing echo functionality. This opens the possibility of using Hsp-PTD fusion protein delivery systems as new anti-apoptotic therapeutics preventing or treating ischemic heart diseases. | - |
dc.publisher | 신약개발연구자협의회 | - |
dc.title | Drug Delivery Systems of Fusion Proteins for the Treatment of Ischemic Heart Disease | - |
dc.type | Conference | - |
dc.contributor.affiliatedAuthor | 김용희 | - |
dc.identifier.bibliographicCitation | 제2회 신약개발연구자협의회 포럼 | - |
dc.relation.isPartOf | 제2회 신약개발연구자협의회 포럼 | - |
dc.citation.title | 제2회 신약개발연구자협의회 포럼 | - |
dc.citation.conferencePlace | 한국과학기술회관 | - |
dc.type.rims | CONF | - |
dc.description.journalClass | 1 | - |
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