Bone mineral density is an independent determinant of left ventricular diastolic function

Abstract

Background: Recent studies reported that osteoporosis is associated with cardiovascular disease. But the relationship between calcium metabolism and left ventricular(LV) diastolic function is quite controversial. Methods: 550 subjects sampled from a general population in YangPyung county, Gyung-Gi, Korea were examined with carotid intima media thickness(IMT) measurement, brachial ankle pulse wave velocity(baPWV) as well as the measurements of blood pressure, blood chemistry, and metabolic parameters. Bone mineral density was measured using The Sahara Clinical Bone Sonometer(Hologic Inc., Mass., USA). LV diastolic function was measured using transmitral E, A, DT, and IVRT. In multiple regression model includes IMT, baPWV, and LVMI to examine if the effect of BMD on LV function is independent. Results: 492 subject data were available for the analysis. Transmitral E was determined by age, gender, pulse pressure, baPWV, and BMD. Transmitral A was determined by pulse pressure, heart rate, smoking, LDL, LVMI, baPWV, antihypertension medication, and BMD. DT was determined by age, IMT, baPWV, LVMI, and BMD. IVRT was determined by age, pulse pressure, IMT, baPWV, and LVMI. E/A ratio was determined by age(β= -0.255), heart rate(β= -0.191), baPWV(β= -0.300), LVMI(β= -0.158), and BMD(β=0.135). In the group of patients with relaxation abnormality(n=104), BMD was lower than the group of normal function(n=388)(4.28 ±0.11 g/cm2 vs 4.77 ± 0.12 g/cm2, p < 0.0001). Conclusion: BMD is an independent factor determining parameters of LV relaxation abnormality except IVRT. BMD is independent of well known factors affecting LV function such as LVMI, IMT, or baPWV.