Facile Synthesis of PEG-Silica Hybrid Particles using One-Step Sol-Gel Reaction in Aqueous Solution

Abstract

A facile synthesis method using one-step sol-gel reaction in aqueous solution is designed in this study. The remodeled sol-gel process is used because it is particularly well suited to create hybrid silica materials and because the particles are formed at low temperature, at which organic groups are not degraded. On the contrary to the general sol-gel methods, our remodeled sol-gel process for hybrid silica particles just needs polymer-silane monomers (PEGME-IPTES, Mw. of PEG: 750, 2000) without other precursors such as tetramethyl orthosilicate (TMOS), tetraethyl orthosilicate (TEOS), and tetrapropyl orthosilicate (TPOS).