Targeted Delivery of siRNA in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상경 | - |
dc.date.accessioned | 2021-08-04T00:22:30Z | - |
dc.date.available | 2021-08-04T00:22:30Z | - |
dc.date.created | 2021-06-30 | - |
dc.date.issued | 2008-01-17 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/65526 | - |
dc.description.abstract | Targeted delivery of siRNA in vivo RNA interference (RNAi) is now increasingly being considered as a promising approach in the therapy of a variety of human diseases including cancers, viral infections, degenerative diseases, and inflammation, to name a few. However, for RNAi to become a feasible clinical application, a major obstacle is efficient delivery of small interfering RNAs (siRNA) to specific target cells and tissues. Targeted delivery of siRNA is essential for maximizing the efficiency of gene-silencing while reducing unwanted side effects. We demonstrate two methods for the delivery siRNA to two different target cell types in animal models, via neurons and T cells, primary cells that are extremely resistant to transfection with nucleic acids. First, we have used a Rabies virus glycoprotein derived peptide as ligand for delivery mediated by binding to its cognate receptor expressed on neuronal cells. As a second approach, we have used a single chain antibody directed to the pan T cell molecule, CD7 for specific delivery to T cells. We demonstrate the viability of both approaches in delivering siRNA and bringing about effective target gene silencing in animal models. | - |
dc.publisher | 연세대학교 의과대학 | - |
dc.title | Targeted Delivery of siRNA in vivo | - |
dc.type | Conference | - |
dc.contributor.affiliatedAuthor | 이상경 | - |
dc.identifier.bibliographicCitation | Avison Biomedical Symposium 2008 | - |
dc.relation.isPartOf | Avison Biomedical Symposium 2008 | - |
dc.citation.title | Avison Biomedical Symposium 2008 | - |
dc.citation.conferencePlace | 세브란스병원 | - |
dc.type.rims | CONF | - |
dc.description.journalClass | 1 | - |
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