Unraveling the Blood Testis Barrier

Abstract

Unraveling the molecular nature and functional regulation of inter-Sertoli TJ is important for understanding the spermatogenesis and development of male contraceptive. On the other hand, possible change in inter-Sertoli TJ by natural and synthetic chemicals such as endocrine disruptors is potentially important for understanding the male reproductive toxicity of certain chemicals. On the other hand, future development of automatic TER monitoring system combined with massive primary culture of Sertoli cells or suitable cell line will decrease labor for studying inter-Sertoli TJ and development for male contraceptive targeted to BTB.