Comparative Study on the Nociceptive Responses Induced by Whole Bee Venom and Melittin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전종헌 | - |
dc.date.accessioned | 2021-08-04T06:50:16Z | - |
dc.date.available | 2021-08-04T06:50:16Z | - |
dc.date.created | 2021-06-30 | - |
dc.date.issued | 2003-10-16 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/76013 | - |
dc.description.abstract | The present study was undertaken to confirm whether mether melittin major constituent of whole bee venom(WBV), had an abilty to product the same nociceptive as those induced by WBV. Changes on mechanical threshold, flinching behaviors and paw thickness (edema) were measured after intraplanrar injection of WBV (0.1 mg & 0.3 mg/paw) and melittin (0.05 mg & 0.15 mg/paw), and intrathecal injection of melittin (6mg).Also studied were the effects of morphine (3 mg & 6 mg/kg,i.p) on melittin-induced pain responses. Intraplantar injection of melittin at half a dorsage of WBV reduced mevhanical threshold, increased flinchings and paw thickness (edema) similar extent to those induced by WBV. Melittin- and WBV-induced flinchings were dose-dependent. Paw thickness increased maximaally about 1hr after melittin and WBV treatmint, and the increased paw thickness (edema) was ,mintained after 6 hours without great differences. <elittin-induced deced decease in mechanical threshold and flinchings were suppressed by i.p morphine. Intrathecal adminisreation of melittin (6mg)redyced mevhanical threshold of peripheral receptive field and induced flinching behaviors, bur did nit caused an increase in paw thickness. These finfings syggest that pain belabiors indyced by WBV were | - |
dc.publisher | The Korean Physiological Society | - |
dc.title | Comparative Study on the Nociceptive Responses Induced by Whole Bee Venom and Melittin | - |
dc.type | Conference | - |
dc.contributor.affiliatedAuthor | 전종헌 | - |
dc.identifier.bibliographicCitation | 55th Annual Meeting The Korean Physiologic Society | - |
dc.relation.isPartOf | 55th Annual Meeting The Korean Physiologic Society | - |
dc.citation.title | 55th Annual Meeting The Korean Physiologic Society | - |
dc.citation.conferencePlace | Chungnam University | - |
dc.type.rims | CONF | - |
dc.description.journalClass | 2 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.