Hepatitis C Virus Cure Rates Are Reduced in Patients With Active but Not Inactive Hepatocellular Carcinoma: A Practice Implication
DC Field | Value | Language |
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dc.contributor.author | Ogawa, Eiichi | - |
dc.contributor.author | Toyoda, Hidenori | - |
dc.contributor.author | Iio, Etsuko | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Huang, Chung-Feng | - |
dc.contributor.author | Enomoto, Masaru | - |
dc.contributor.author | Hsu, Yao-Chun | - |
dc.contributor.author | Haga, Hiroaki | - |
dc.contributor.author | Iwane, Shinji | - |
dc.contributor.author | Wong, Grace | - |
dc.contributor.author | Lee, Dong Hyun | - |
dc.contributor.author | Tada, Toshifumi | - |
dc.contributor.author | Liu, Chen-Hua | - |
dc.contributor.author | Chuang, Wan-Long | - |
dc.contributor.author | Hayashi, Jun | - |
dc.contributor.author | Cheung, Ramsey | - |
dc.contributor.author | Yasuda, Satoshi | - |
dc.contributor.author | Tseng, Cheng-Hao | - |
dc.contributor.author | Takahashi, Hirokazu | - |
dc.contributor.author | Tran, Sally | - |
dc.contributor.author | Yeo, Yee Hui | - |
dc.contributor.author | Henry, Linda | - |
dc.contributor.author | Barnett, Scott D. | - |
dc.contributor.author | Nomura, Hideyuki | - |
dc.contributor.author | Nakamuta, Makoto | - |
dc.contributor.author | Dai, Chia-Yen | - |
dc.contributor.author | Huang, Jee-Fu | - |
dc.contributor.author | Yang, Hwai-, I | - |
dc.contributor.author | Lee, Mei-Hsuan | - |
dc.contributor.author | Jun, Mi Jung | - |
dc.contributor.author | Kao, Jia-Horng | - |
dc.contributor.author | Eguchi, Yuichiro | - |
dc.contributor.author | Ueno, Yoshiyuki | - |
dc.contributor.author | Tamori, Akihiro | - |
dc.contributor.author | Furusyo, Norihiro | - |
dc.contributor.author | Yu, Ming-Lung | - |
dc.contributor.author | Tanaka, Yasuhito | - |
dc.contributor.author | Nguyen, Mindie H. | - |
dc.date.accessioned | 2021-08-02T08:28:33Z | - |
dc.date.available | 2021-08-02T08:28:33Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/8165 | - |
dc.description.abstract | Background. Cure rates of hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) for patients with active and inactive hepatocellular carcinoma (HCC) may differ, but well-controlled studies are limited. We aimed to evaluate DAA outcomes in a large East Asian HCV/HCC population compared with HCV/non-HCC patients. Methods. Using data from the Real-World Evidence from the Asia Liver Consortium (REAL-C) registry (Hong Kong, Japan, South Korea, and Taiwan), we used propensity score matching (PSM) to match HCC and non-HCC (1:1) groups for age, sex, cirrhosis, prior treatment, HCV genotype, treatment regimen, baseline platelet count, HCV RNA, total bilirubin, alanine aminotransferase, and albumin levels to evaluate DAA treatment outcomes in a large population of HCV/HCC compared with HCV/non-HCC patients. Results. We included 6081 patients (HCC, n = 465; non-HCC, n = 5 616) treated with interferon-free DAAs. PSM of the entire study population yielded 436 matched pairs with similar baseline characteristics. There was no statistically significant difference in the overall SVR rate of HCC (92.7%) and non-HCC (95.0%) groups. Rates of treatment discontinuation, adverse effects, and death were also similar between HCC and non-HCC groups. Among patients with HCC, those with active HCC had a lower SVR than inactive HCC cases (85.5% vs 93.7%; P = .03). On multivariable analysis, active HCC, but not inactive HCC, was significantly associated with lower SVR (OR, 0.28; P = .01) when compared with non-HCC. Conclusions. Active HCC but not inactive HCC was independently associated with lower SVR compared with non-HCC patients undergoing DAA therapy, although cure rate was still relatively high (85%) in active HCC patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Hepatitis C Virus Cure Rates Are Reduced in Patients With Active but Not Inactive Hepatocellular Carcinoma: A Practice Implication | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.identifier.doi | 10.1093/cid/ciz1160 | - |
dc.identifier.scopusid | 2-s2.0-85099326545 | - |
dc.identifier.wosid | 000607829500013 | - |
dc.identifier.bibliographicCitation | CLINICAL INFECTIOUS DISEASES, v.71, no.11, pp.2840 - 2848 | - |
dc.relation.isPartOf | CLINICAL INFECTIOUS DISEASES | - |
dc.citation.title | CLINICAL INFECTIOUS DISEASES | - |
dc.citation.volume | 71 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2840 | - |
dc.citation.endPage | 2848 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | GENOTYPE DISTRIBUTION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | ANTIVIRALS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | direct-acting antivirals | - |
dc.subject.keywordAuthor | Asian | - |
dc.subject.keywordAuthor | propensity score matching | - |
dc.identifier.url | https://academic.oup.com/cid/article/71/11/2840/5645107 | - |
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