Sex differences in clinical characteristics and long-term outcomes in patients with vasospastic angina: results from the VA-Korea registry, a prospective multi-center cohort
DC Field | Value | Language |
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dc.contributor.author | Kim, Hack-Lyoung | - |
dc.contributor.author | Jo, Sang-Ho | - |
dc.contributor.author | Kim, Hyun-Jin | - |
dc.contributor.author | Lee, Min-Ho | - |
dc.contributor.author | Seo, Won-Woo | - |
dc.contributor.author | Baek, Sang Hong | - |
dc.date.accessioned | 2021-08-02T08:51:17Z | - |
dc.date.available | 2021-08-02T08:51:17Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2042-6410 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/8847 | - |
dc.description.abstract | Background: Sex differences in clinical characteristics and prognosis of vasospastic angina (VA) have not been well elucidated. This study was performed to investigate sex-specific characteristics and predictors for long-term clinical outcomes in patients with VA. Methods: We analyzed 1838 patients (55 years and 62% male) who were diagnosed with definite (n = 680) or intermediate (n = 1212) VA in ergonovine provocation test from a nation-wide VA registry. The primary study end-point was composite events including cardiac death, acute coronary syndrome, ventricular tachycardia or fibrillation, and atrioventricular block during clinical follow-up. Results: Male patients were younger, and there were more smokers and alcohol drinkers in male patients than in female patients. During the median follow-up period of 760 days (interquartile range, 336–1105 days), there were 73 cases (3.97%) of composite events. There was no sex difference in the occurrence of composite events (log-rank p = 0.649). Concomitant significant (≥ 50%) organic coronary stenosis was associated with worse clinical outcomes in both male (hazard ration [HR], 1.97; 95% confidence interval [CI], 1.01–3.85; p = 0.047) and female (HR, 3.26; 95% CI, 1.07–9.89; p = 0.037) patients. Obesity (body mass index ≥ 25 kg/m²) was associated with better prognosis in female VA patients (HR, 0.22; 95% CI, 0.07–0.68; p = 0.008). Even when only patients with definite diagnosis of VA were considered, there was no significant sex difference in clinical outcomes (log-rank p = 0.876). Conclusions: In VA patients, there were several different clinical characteristics according to sex; however, long-term clinical outcome was similar between sexes. Significant organic coronary stenosis in both sexes and low body mass index (< 25 kg/m2) in females were associated with worse prognosis in VA patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.title | Sex differences in clinical characteristics and long-term outcomes in patients with vasospastic angina: results from the VA-Korea registry, a prospective multi-center cohort | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Jin | - |
dc.identifier.doi | 10.1186/s13293-020-00341-4 | - |
dc.identifier.scopusid | 2-s2.0-85096427752 | - |
dc.identifier.wosid | 000595681400003 | - |
dc.identifier.bibliographicCitation | BIOLOGY OF SEX DIFFERENCES, v.11, no.1, pp.1 - 11 | - |
dc.relation.isPartOf | BIOLOGY OF SEX DIFFERENCES | - |
dc.citation.title | BIOLOGY OF SEX DIFFERENCES | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | CORONARY-ARTERY SPASM | - |
dc.subject.keywordPlus | GENDER-DIFFERENCES | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ARRHYTHMIAS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordAuthor | Clinical characteristics | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Sex difference | - |
dc.subject.keywordAuthor | Vasospastic angina | - |
dc.identifier.url | https://bsd.biomedcentral.com/articles/10.1186/s13293-020-00341-4 | - |
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