Effects of vitamin D supplements in patients with chronic hepatitis C: a randomized, multi-center, open label study
DC Field | Value | Language |
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dc.contributor.author | Jeong, Jae Yoon | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Park, Sol Ji | - |
dc.contributor.author | Sohn, Joo Hyun | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Lee, Se Whan | - |
dc.contributor.author | Jeong, Soung Won | - |
dc.contributor.author | Kim, Moon Young | - |
dc.contributor.author | Kim, Won | - |
dc.contributor.author | Shim, Jae-Jun | - |
dc.contributor.author | Kim, Hyoung Su | - |
dc.contributor.author | Suk, Ki Tae | - |
dc.contributor.author | Ahn, Sang Bong | - |
dc.date.accessioned | 2021-08-02T08:52:25Z | - |
dc.date.available | 2021-08-02T08:52:25Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/8942 | - |
dc.description.abstract | Background/Aims: We aimed to assess the role of vitamin D supplementation in the response to pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV) treatment in patients with chronic hepatitis C (CHC). Methods: Our study was a multi-center, randomized controlled trial in 11 hospitals. CHC patients were randomly assigned (1:1) to two groups namely, PEGIFN-α plus RBV (control group) or PEG-IFN-α plus RBV + vitamin D (800 IU daily) (vitamin D group). The primary end-point was the rate of sustained virologic response (SVR). Results: One hundred forty eight CHC patients were randomly assigned to two groups. Seventy-one patients received the PEG-IFN-α plus RBV and 77 patients received the PEG-IFN-α plus RBV + vitamin D. A total of 105 patients completed the study (control group, 47 vs. vitamin D group, 58). Baseline characteristics were mostly similar in both the groups. There was a modest but non-significant increase in SVR in the vitamin D group compared to the control group with the intention to treat analysis (64.0% vs. 49.3 %, p = 0.071) as well as in the per protocol analysis (control group vs. vitamin D group: 74.5% vs. 84.5%, p = 0.202). Fifty-two patients (73.2%) in the control group and 63 patients (81.8%) in the vitamin D group experienced at least one adverse event. The drop-out rate due to adverse effects was not different between both groups (control group vs. vitamin D group: 19.7% vs. 10.4%, p = 0.111). Conclusions: Vitamin D supplement did not increase SVR in treatment naïve patients with CHC irrespective of genotype. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.title | Effects of vitamin D supplements in patients with chronic hepatitis C: a randomized, multi-center, open label study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.contributor.affiliatedAuthor | Sohn, Joo Hyun | - |
dc.identifier.doi | 10.3904/kjim.2018.273 | - |
dc.identifier.scopusid | 2-s2.0-85086915703 | - |
dc.identifier.wosid | 000564331000007 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.35, no.5, pp.1074 - 1083 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1074 | - |
dc.citation.endPage | 1083 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002616009 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | SUSTAINED VIROLOGICAL RESPONSE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | D DEFICIENCY | - |
dc.subject.keywordPlus | PARATHYROID-HORMONE | - |
dc.subject.keywordPlus | 25-HYDROXYVITAMIN D | - |
dc.subject.keywordPlus | LIVER FIBROSIS | - |
dc.subject.keywordPlus | D INADEQUACY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordAuthor | Chronic hepatitis C | - |
dc.subject.keywordAuthor | Vitamin D | - |
dc.subject.keywordAuthor | Sustained virologic response | - |
dc.identifier.url | https://www.kjim.org/journal/view.php?doi=10.3904/kjim.2018.273 | - |
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