In SilicoAnalysis of the Antigenic Properties of Iron-Regulated Proteins againstNeisseria meningitidis
DC Field | Value | Language |
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dc.contributor.author | Rahman, Shahedur | - |
dc.contributor.author | Biswas, Chayon | - |
dc.contributor.author | Biswas, Polash Kumar | - |
dc.contributor.author | Kader, Md Ashraful | - |
dc.contributor.author | Alam, S. M. Nur | - |
dc.contributor.author | Sonne, Christian | - |
dc.contributor.author | Kim, Ki-Hyun | - |
dc.date.accessioned | 2021-08-02T08:52:30Z | - |
dc.date.available | 2021-08-02T08:52:30Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/8951 | - |
dc.description.abstract | Neisseria meningitidisis a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal forN. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine againstN. meningitidis. The basic properties ofN. meningitidisOMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine againstN. meningitidisbothin vitroandin vivo. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | In SilicoAnalysis of the Antigenic Properties of Iron-Regulated Proteins againstNeisseria meningitidis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ki-Hyun | - |
dc.identifier.doi | 10.3390/app10176113 | - |
dc.identifier.scopusid | 2-s2.0-85090394794 | - |
dc.identifier.wosid | 000571231000001 | - |
dc.identifier.bibliographicCitation | APPLIED SCIENCES-BASEL, v.10, no.17, pp.1 - 12 | - |
dc.relation.isPartOf | APPLIED SCIENCES-BASEL | - |
dc.citation.title | APPLIED SCIENCES-BASEL | - |
dc.citation.volume | 10 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | ANTIMICROBIAL PEPTIDE RESISTANCE | - |
dc.subject.keywordPlus | OUTER-MEMBRANE PROTEIN | - |
dc.subject.keywordPlus | HIGH EPITOPE DENSITY | - |
dc.subject.keywordPlus | NEISSERIA-MENINGITIDIS | - |
dc.subject.keywordPlus | DNA VACCINE | - |
dc.subject.keywordPlus | FRPB | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | MOLECULE | - |
dc.subject.keywordAuthor | Neisseria meningitidis | - |
dc.subject.keywordAuthor | vaccine development | - |
dc.subject.keywordAuthor | epidemic disease | - |
dc.subject.keywordAuthor | immunogenicity | - |
dc.identifier.url | https://www.mdpi.com/2076-3417/10/17/6113 | - |
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