Hepatic stellate cell-specific knockout of transcriptional intermediary factor 1 gamma aggravates liver fibrosis
DC Field | Value | Language |
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dc.contributor.author | Lee, Eun Ju | - |
dc.contributor.author | Hwang, Injoo | - |
dc.contributor.author | Lee, Ji Yeon | - |
dc.contributor.author | Park, Jong Nam | - |
dc.contributor.author | Kim, Keun Cheon | - |
dc.contributor.author | Kim, Irene | - |
dc.contributor.author | Moon, Dodam | - |
dc.contributor.author | Park, Hyomin | - |
dc.contributor.author | Lee, Seo-Yeon | - |
dc.contributor.author | Kim, Hong Sug | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2021-08-02T09:27:19Z | - |
dc.date.available | 2021-08-02T09:27:19Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/9786 | - |
dc.description.abstract | Transforming growth factor β (TGFβ) is a crucial factor in fibrosis, and transcriptional intermediary factor 1γ (TIF1γ) is a negative regulator of the TGFβ pathway; however, its role in liver fibrosis is unknown. In this study, mesenchymal stem cells derived from human embryonic stem cells (hE-MSCs) that secrete hepatocyte growth factor (HGF) were used to observe the repair of thioacetamide (TAA)-induced liver fibrosis. Our results showed that TIF1γ was significantly decreased in LX2 cells when exposed to TGFβ1. Such decrease of TIF1γ was significantly prevented by co-culture with hE-MSCs. Interaction of TIF1γ with SMAD2/3 and binding to the promoter of the α-smooth muscle gene (αSMA) suppressed αSMA expression. Phosphorylation of cAMP response element–binding protein (CREB) and binding on the TIF1γ promoter region induced TIF1γ expression. Furthermore, hepatic stellate cell–specific TIF1γ-knockout mice showed aggravation of liver fibrosis. In conclusion, loss of TIF1γ aggravates fibrosis, suggesting that a strategy to maintain TIF1γ during liver injury would be a promising therapeutic approach to prevent or reverse liver fibrosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | Hepatic stellate cell-specific knockout of transcriptional intermediary factor 1 gamma aggravates liver fibrosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.identifier.doi | 10.1084/jem.20190402 | - |
dc.identifier.scopusid | 2-s2.0-85086662173 | - |
dc.identifier.wosid | 000538138000001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, v.217, no.6, pp.1 - 22 | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 217 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 22 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | NEGATIVE REGULATOR | - |
dc.subject.keywordPlus | SMAD4 | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | TRANSITION | - |
dc.subject.keywordPlus | TIF1-GAMMA | - |
dc.subject.keywordPlus | IMPROVES | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | FATE | - |
dc.identifier.url | https://rupress.org/jem/article/217/6/e20190402/151632/Hepatic-stellate-cell-specific-knockout-of | - |
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