Selective red-emission detection for mercuric ions in aqueous solution and cells using a fluorescent probe based on an unnatural peptide receptor
DC Field | Value | Language |
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dc.contributor.author | Neupane, Lok Nath | - |
dc.contributor.author | Mehta, Pramod Kumar | - |
dc.contributor.author | Kwon, Joon-Uk | - |
dc.contributor.author | Park, See-Hyoung | - |
dc.contributor.author | Lee, Keun-Hyeung | - |
dc.date.available | 2020-07-10T03:37:02Z | - |
dc.date.created | 2020-07-06 | - |
dc.date.issued | 2019-04-14 | - |
dc.identifier.issn | 1477-0520 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/1755 | - |
dc.description.abstract | The selective ratiometric red-emission detection of Hg2+ ions in aqueous buffered solutions and live cells is still a significant challenge. In the present study, we synthesized a fluorescent probe (1) based on an unnatural peptide receptor containing sulfonamide groups with an aggregation-induced emission and twisted internal charge transfer (TICT)-active fluorophore, cyanostilbene. 1 exhibited a highly selective ratiometric response to Hg2+ among 14 metal ions tested by ratiometric red-emission at 600 nm, with a clear isoemissive point in purely aqueous solution containing 1% DMSO. The ratiometric response for Hg2+ ions was complete within 3 min and the ratiometric responses induced by Hg2+ ions did not suffer considerable interference from the other metal ions. The ratiometric response was complete for less than 7 M Hg2+ and 1 had a potent binding affinity (7.42 x 10(-6) M, R-2 = 0.98) for Hg2+ and a nanomolar detection limit. 1 detected Hg2+ ions by ratiometric responses in aqueous buffered solutions over a wide range of pH (5.5-11.5). Binding mode studies using TEM, NMR, IR, and a mass spectrometer revealed that the sulfonamide groups of the unnatural peptide receptor played an important role in the complexation of Hg2+ and in the complexation-induced nano-sized aggregates, which resulted in a significant increase in emissions at 600 nm and a decrease in emissions at 535 nm. 1 quantified micro-molar concentrations (0-6 M) of Hg2+ in tap water and groundwater by ratiometric detection. Furthermore, 1 passed through the lipid membranes of live cells and detected intracellular Hg2+ ions at 2 M by a ratiometric red-emission change. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | AGGREGATION-INDUCED EMISSION | - |
dc.subject | SENSITIVE RATIOMETRIC DETECTION | - |
dc.subject | HEAVY-METAL IONS | - |
dc.subject | ON CHEMOSENSOR | - |
dc.subject | HG(II) IONS | - |
dc.subject | LIVE CELLS | - |
dc.subject | HG2+ | - |
dc.subject | SENSOR | - |
dc.subject | TETRAPHENYLETHYLENE | - |
dc.subject | NANOPARTICLES | - |
dc.title | Selective red-emission detection for mercuric ions in aqueous solution and cells using a fluorescent probe based on an unnatural peptide receptor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, See-Hyoung | - |
dc.identifier.doi | 10.1039/c8ob03224f | - |
dc.identifier.scopusid | 2-s2.0-85064059232 | - |
dc.identifier.wosid | 000465615200013 | - |
dc.identifier.bibliographicCitation | ORGANIC & BIOMOLECULAR CHEMISTRY, v.17, no.14, pp.3590 - 3598 | - |
dc.relation.isPartOf | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.citation.title | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 3590 | - |
dc.citation.endPage | 3598 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | AGGREGATION-INDUCED EMISSION | - |
dc.subject.keywordPlus | SENSITIVE RATIOMETRIC DETECTION | - |
dc.subject.keywordPlus | HEAVY-METAL IONS | - |
dc.subject.keywordPlus | ON CHEMOSENSOR | - |
dc.subject.keywordPlus | HG(II) IONS | - |
dc.subject.keywordPlus | LIVE CELLS | - |
dc.subject.keywordPlus | HG2+ | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | TETRAPHENYLETHYLENE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
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