Microtechnology-based in vitro models: Mimicking liver function and pathophysiology
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung Yeon | - |
dc.contributor.author | Kim, Donghyun | - |
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | Sung, Jong Hwan | - |
dc.date.accessioned | 2021-11-17T05:40:37Z | - |
dc.date.available | 2021-11-17T05:40:37Z | - |
dc.date.created | 2021-11-15 | - |
dc.date.issued | 2021-12-01 | - |
dc.identifier.issn | 2473-2877 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/18088 | - |
dc.description.abstract | The liver plays important roles in drug metabolism and homeostasis. The metabolism and biotransformation can not only affect the efficacy of drugs but also result in hepatotoxicity and drug-induced liver injury. Understanding the complex physiology of the liver and the pathogenetic mechanisms of liver diseases is essential for drug development. Conventional in vitro models have limitations in the ability to predict drug effects, due to the lack of physiological relevance. Recently, the liver-on-a-chip platform has been developed to reproduce the microarchitecture and in vivo environment of the liver. These efforts have improved the physiological relevance of the liver tissue used in the platform and have demonstrated its applicability to drug screening and disease models. In this review, we summarize the recent development of liver-on-a-chip models that closely mimic the in vivo liver environments and liver diseases.& nbsp;& nbsp;(C) 2021 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license </p> | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AIP Publishing | - |
dc.subject | ON-A-CHIP | - |
dc.subject | 3-DIMENSIONAL CELL-CULTURE | - |
dc.subject | TOTAL BIOASSAY SYSTEM | - |
dc.subject | MICROPHYSIOLOGICAL SYSTEMS | - |
dc.subject | INTESTINAL-ABSORPTION | - |
dc.subject | MICROFLUIDIC PLATFORM | - |
dc.subject | HEPATIC-METABOLISM | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | HUMAN HEPATOCYTES | - |
dc.subject | RAT HEPATOCYTES | - |
dc.title | Microtechnology-based in vitro models: Mimicking liver function and pathophysiology | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sung, Jong Hwan | - |
dc.identifier.doi | 10.1063/5.0061896 | - |
dc.identifier.scopusid | 2-s2.0-85117255717 | - |
dc.identifier.wosid | 000710496200001 | - |
dc.identifier.bibliographicCitation | APL BIOENGINEERING, v.5, no.4 | - |
dc.relation.isPartOf | APL BIOENGINEERING | - |
dc.citation.title | APL BIOENGINEERING | - |
dc.citation.volume | 5 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.subject.keywordPlus | ON-A-CHIP | - |
dc.subject.keywordPlus | 3-DIMENSIONAL CELL-CULTURE | - |
dc.subject.keywordPlus | TOTAL BIOASSAY SYSTEM | - |
dc.subject.keywordPlus | MICROPHYSIOLOGICAL SYSTEMS | - |
dc.subject.keywordPlus | INTESTINAL-ABSORPTION | - |
dc.subject.keywordPlus | MICROFLUIDIC PLATFORM | - |
dc.subject.keywordPlus | HEPATIC-METABOLISM | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | HUMAN HEPATOCYTES | - |
dc.subject.keywordPlus | RAT HEPATOCYTES | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
94, Wausan-ro, Mapo-gu, Seoul, 04066, Korea02-320-1314
COPYRIGHT 2020 HONGIK UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.