pH-Responsive Hydrogel Microparticles as Intelligent Delivery Carriers for alpha-MSH Antagonists
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Juseung | - |
dc.contributor.author | Cho, Geundo | - |
dc.contributor.author | Lee, Tai-Gyu | - |
dc.contributor.author | Kim, Bumsang | - |
dc.date.accessioned | 2021-12-15T02:42:38Z | - |
dc.date.available | 2021-12-15T02:42:38Z | - |
dc.date.created | 2021-12-10 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0001-1541 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/19852 | - |
dc.description.abstract | For a first step in the development of an intelligent delivery system for a nonapeptide as an alpha-MSH antagonist, pH-responsive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as intelligent delivery carriers was evaluated. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of around 5 and as the MAA amount in the hydrogel increased, the swelling ratio increased at a pH above 5. The loading efficiency of the nonapeptide at pH 7 increased with the amount of Methacrylic acid (MAA) in the hydrogel and at pH 2, where the electrostatic attraction was greatest, a high loading efficiency was not obtained because of the low swelling ratio of the hydrogel. The P(MAA-co-EGMA) microparticles demonstrated a pH-sensitive release behavior for the nonapeptide. In addition, the P(MAA-co-EGMA) microparticles showed a protective ability for the nonapeptide and preserved the stability of the nonapeptide. (C) 2010 American Institute of Chemical Engineers AIChE J, 57: 1919-1925, 2011 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | MELANOCYTE-STIMULATING HORMONE | - |
dc.subject | MELANOCORTIN RECEPTORS | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | CELLS | - |
dc.subject | TYROSINASE | - |
dc.subject | ACTIVATION | - |
dc.subject | MOLECULES | - |
dc.title | pH-Responsive Hydrogel Microparticles as Intelligent Delivery Carriers for alpha-MSH Antagonists | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Bumsang | - |
dc.identifier.doi | 10.1002/aic.12407 | - |
dc.identifier.scopusid | 2-s2.0-79958715443 | - |
dc.identifier.wosid | 000291803800027 | - |
dc.identifier.bibliographicCitation | AICHE JOURNAL, v.57, no.7, pp.1919 - 1925 | - |
dc.relation.isPartOf | AICHE JOURNAL | - |
dc.citation.title | AICHE JOURNAL | - |
dc.citation.volume | 57 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1919 | - |
dc.citation.endPage | 1925 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | MELANOCYTE-STIMULATING HORMONE | - |
dc.subject.keywordPlus | MELANOCORTIN RECEPTORS | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordAuthor | hydrogel microparticles | - |
dc.subject.keywordAuthor | pH-responsive | - |
dc.subject.keywordAuthor | intelligent delivery system | - |
dc.subject.keywordAuthor | alpha-MSH antagonists | - |
dc.subject.keywordAuthor | skin permeability | - |
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