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pH-Responsive Hydrogel Microparticles as Intelligent Delivery Carriers for alpha-MSH Antagonists

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dc.contributor.authorYang, Juseung-
dc.contributor.authorCho, Geundo-
dc.contributor.authorLee, Tai-Gyu-
dc.contributor.authorKim, Bumsang-
dc.date.accessioned2021-12-15T02:42:38Z-
dc.date.available2021-12-15T02:42:38Z-
dc.date.created2021-12-10-
dc.date.issued2011-07-
dc.identifier.issn0001-1541-
dc.identifier.urihttps://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/19852-
dc.description.abstractFor a first step in the development of an intelligent delivery system for a nonapeptide as an alpha-MSH antagonist, pH-responsive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as intelligent delivery carriers was evaluated. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of around 5 and as the MAA amount in the hydrogel increased, the swelling ratio increased at a pH above 5. The loading efficiency of the nonapeptide at pH 7 increased with the amount of Methacrylic acid (MAA) in the hydrogel and at pH 2, where the electrostatic attraction was greatest, a high loading efficiency was not obtained because of the low swelling ratio of the hydrogel. The P(MAA-co-EGMA) microparticles demonstrated a pH-sensitive release behavior for the nonapeptide. In addition, the P(MAA-co-EGMA) microparticles showed a protective ability for the nonapeptide and preserved the stability of the nonapeptide. (C) 2010 American Institute of Chemical Engineers AIChE J, 57: 1919-1925, 2011-
dc.language영어-
dc.language.isoen-
dc.publisherWILEY-BLACKWELL-
dc.subjectMELANOCYTE-STIMULATING HORMONE-
dc.subjectMELANOCORTIN RECEPTORS-
dc.subjectPROTEIN-KINASE-
dc.subjectDRUG-DELIVERY-
dc.subjectCELLS-
dc.subjectTYROSINASE-
dc.subjectACTIVATION-
dc.subjectMOLECULES-
dc.titlepH-Responsive Hydrogel Microparticles as Intelligent Delivery Carriers for alpha-MSH Antagonists-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Bumsang-
dc.identifier.doi10.1002/aic.12407-
dc.identifier.scopusid2-s2.0-79958715443-
dc.identifier.wosid000291803800027-
dc.identifier.bibliographicCitationAICHE JOURNAL, v.57, no.7, pp.1919 - 1925-
dc.relation.isPartOfAICHE JOURNAL-
dc.citation.titleAICHE JOURNAL-
dc.citation.volume57-
dc.citation.number7-
dc.citation.startPage1919-
dc.citation.endPage1925-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalWebOfScienceCategoryEngineering, Chemical-
dc.subject.keywordPlusMELANOCYTE-STIMULATING HORMONE-
dc.subject.keywordPlusMELANOCORTIN RECEPTORS-
dc.subject.keywordPlusPROTEIN-KINASE-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusTYROSINASE-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusMOLECULES-
dc.subject.keywordAuthorhydrogel microparticles-
dc.subject.keywordAuthorpH-responsive-
dc.subject.keywordAuthorintelligent delivery system-
dc.subject.keywordAuthoralpha-MSH antagonists-
dc.subject.keywordAuthorskin permeability-
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